Document Detail


Peritonitis due to Aspergillus and zygomycetes in patients undergoing peritoneal dialysis: report of 2 cases and review of the literature.
MedLine Citation:
PMID:  12742319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fungal peritonitis in patients on continuous ambulatory peritoneal dialysis (CAPD) has been associated with high mortality and high CAPD-discontinuation rates. Most cases are due to Candida spp. while Aspergillus spp. and zygomycetes have only rarely been implicated. We report one case each of CAPD-related peritonitis caused by Aspergillus terreus and Mucor sp., which have previously been described in the literature once and twice, respectively. The former had a slowly progressive course, did not respond to amphotericin B (AB), and died; the latter improved after a prolonged course of liposomal-AB. Among reported cases of CAPD-related peritonitis due to molds (22 Aspergillus spp. and seven zygomycetes), previous bacterial peritonitis was a common event, the related mortality associated with Aspergillus and zygomycetes was 27% and 57%, respectively, prompt removal of the Tenckoff catheter was critical for survival, and most patients were not able to resume CAPD.
Authors:
Esteban C Nannini; Niki I Paphitou; Luis Ostrosky-Zeichner
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Diagnostic microbiology and infectious disease     Volume:  46     ISSN:  0732-8893     ISO Abbreviation:  Diagn. Microbiol. Infect. Dis.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-13     Completed Date:  2003-07-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8305899     Medline TA:  Diagn Microbiol Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
Affiliation:
Division of Infectious Diseases, Department of Internal Medicine, The University of Texas Medical School, Houston, Texas, USA. Esteban.C.Nannini@uth.tmc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Antifungal Agents / therapeutic use
Aspergillosis / diagnosis,  drug therapy
Aspergillus fumigatus / isolation & purification*
Follow-Up Studies
Fungi / isolation & purification*
Humans
Male
Mycoses / diagnosis,  drug therapy
Peritoneal Dialysis, Continuous Ambulatory / adverse effects*,  methods
Peritonitis / drug therapy,  etiology*,  microbiology
Risk Assessment
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antifungal Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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