Document Detail

Peritonitis, dialysate infusion and lung function in continuous ambulatory peritoneal dialysis (CAPD).
MedLine Citation:
PMID:  3930114     Owner:  NLM     Status:  MEDLINE    
Pulmonary function tests were done in seven CAPD patients with acute peritonitis on the day of admission to the hospital and after recovery. Subsequently, the effect of dialysate infusion alone on lung function was studied in 19 patients initiated on CAPD and nine of these patients were restudied 7.6 +/- 4.1 months later. Peritonitis was associated with a 30% reduction in vital capacity and a significant fall in arterial oxygen tension (7 to 11 mmHg) (p less than 0.01). Dialysate infusion alone decreased functional residual capacity (FRC) and produced small changes in PaO2 which were more pronounced in the supine position. The decrease in PaO2 observed in changing from sitting prior to dialysate infusion, to supine after dialysate infusion was due to the development of airways closure at resting lung volumes. Follow-up studies in nine patients demonstrated a continued and significant fall in FRC with dialysate infusion, without however, any changes in PaO2. We conclude that peritonitis in CAPD patients is accompanied by significant changes in lung function which are probably due to a decrease in diaphragmatic mobility resulting in atelectasis and underventilation of dependent lung zones. In CAPD patients without peritonitis, dialysate infusion in the supine position produces significant changes in PaO2, but with time, compensatory mechanisms develop to abolish the changes in PaO2.
A M Taveira da Silva; W B Davis; J F Winchester; D E Coleman; C W Weir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical nephrology     Volume:  24     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-11-21     Completed Date:  1985-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  79-83     Citation Subset:  IM    
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MeSH Terms
Carbon Dioxide / blood
Closing Volume
Functional Residual Capacity
Hydrogen-Ion Concentration
Lung / physiopathology*
Lung Volume Measurements
Middle Aged
Oxygen / blood
Peritoneal Dialysis, Continuous Ambulatory / adverse effects*
Peritonitis / etiology*
Prospective Studies
Respiratory Function Tests
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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