Document Detail


Peritoneal seeding following potentially curative resection of colonic carcinoma: implications for adjuvant therapy.
MedLine Citation:
PMID:  1855433     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adjuvant therapeutic strategies for colon cancer are based on the knowledge of tumor recurrence patterns following potentially curative resection. Innovative methods for regional delivery of chemotherapy to the liver and peritoneal surfaces are now available to complement systemic treatment. We reviewed clinical, reoperation, and autopsy series to determine the incidence of peritoneal seeding following colon cancer resection. The data suggest a 25-35 percent peritoneal failure rate among patients that recur, indicating that intraperitoneal chemotherapy is a sensible adjuvant approach. The theory behind intraperitoneal chemotherapy and potential complications is discussed. We suggest initiation of clinical trials combining systemic and intraperitoneal chemotherapy.
Authors:
J T Brodsky; A M Cohen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  34     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-08-29     Completed Date:  1991-08-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  723-7     Citation Subset:  IM    
Affiliation:
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / administration & dosage
Autopsy
Colonic Neoplasms / drug therapy,  surgery*
Combined Modality Therapy
Humans
Neoplasm Metastasis / prevention & control
Neoplasm Recurrence, Local / prevention & control
Neoplasm Seeding*
Reoperation
Chemical
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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