Document Detail

Peritoneal penetration of amphotericin B lipid complex and fluconazole in a pediatric patient with fungal peritonitis.
MedLine Citation:
PMID:  10649734     Owner:  NLM     Status:  MEDLINE    
Fungal peritonitis is a rare event in patients receiving peritoneal dialysis. This case report describes the blood and dialysate concentrations of fluconazole and amphotericin B following intravenous administration in a 5-month-old infant with Candida albicans peritonitis receiving continuous cyclic peritoneal dialysis. Fluconazole rapidly and efficiently penetrated the peritoneal fluid achieving concentrations that exceed the minimal inhibitory concentration (MIC) for most Candida species. In contrast, the amount of amphotericin B in the dialysate was below the limit of quantification despite measurable blood concentrations. This suggests that fluconazole represents a better choice for antifungal therapy because of its excellent peritoneal penetration.
D L Blowey; U C Garg; G L Kearns; B A Warady
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Advances in peritoneal dialysis. Conference on Peritoneal Dialysis     Volume:  14     ISSN:  1197-8554     ISO Abbreviation:  Adv Perit Dial     Publication Date:  1998  
Date Detail:
Created Date:  2000-02-10     Completed Date:  2000-02-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9104803     Medline TA:  Adv Perit Dial     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  247-50     Citation Subset:  IM    
Department of Pediatrics, University of Missouri-Kansas City, USA.
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MeSH Terms
Amphotericin B / administration & dosage,  pharmacokinetics*
Antifungal Agents / administration & dosage,  pharmacokinetics*
Ascitic Fluid / chemistry*
Candidiasis / drug therapy*,  etiology,  metabolism
Drug Combinations
Drug Therapy, Combination
Fluconazole / administration & dosage,  pharmacokinetics*
Infusions, Intravenous
Peritoneal Dialysis / adverse effects*
Peritonitis / drug therapy*,  etiology,  metabolism
Phosphatidylcholines / administration & dosage,  pharmacokinetics*
Phosphatidylglycerols / administration & dosage,  pharmacokinetics*
Grant Support
5 U01 HD 31313-05/HD/NICHD NIH HHS
Reg. No./Substance:
0/Antifungal Agents; 0/Drug Combinations; 0/Phosphatidylcholines; 0/Phosphatidylglycerols; 0/liposomal amphotericin B; 1397-89-3/Amphotericin B; 86386-73-4/Fluconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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