| Peritoneal penetration of amphotericin B lipid complex and fluconazole in a pediatric patient with fungal peritonitis. | |
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MedLine Citation:
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PMID: 10649734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fungal peritonitis is a rare event in patients receiving peritoneal dialysis. This case report describes the blood and dialysate concentrations of fluconazole and amphotericin B following intravenous administration in a 5-month-old infant with Candida albicans peritonitis receiving continuous cyclic peritoneal dialysis. Fluconazole rapidly and efficiently penetrated the peritoneal fluid achieving concentrations that exceed the minimal inhibitory concentration (MIC) for most Candida species. In contrast, the amount of amphotericin B in the dialysate was below the limit of quantification despite measurable blood concentrations. This suggests that fluconazole represents a better choice for antifungal therapy because of its excellent peritoneal penetration. |
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Authors:
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D L Blowey; U C Garg; G L Kearns; B A Warady |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Advances in peritoneal dialysis. Conference on Peritoneal Dialysis Volume: 14 ISSN: 1197-8554 ISO Abbreviation: Adv Perit Dial Publication Date: 1998 |
Date Detail:
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Created Date: 2000-02-10 Completed Date: 2000-02-10 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9104803 Medline TA: Adv Perit Dial Country: CANADA |
Other Details:
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Languages: eng Pagination: 247-50 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Missouri-Kansas City, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amphotericin B
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administration & dosage,
pharmacokinetics* Antifungal Agents / administration & dosage, pharmacokinetics* Ascitic Fluid / chemistry* Candidiasis / drug therapy*, etiology, metabolism Drug Combinations Drug Therapy, Combination Fluconazole / administration & dosage, pharmacokinetics* Humans Infant Infusions, Intravenous Male Peritoneal Dialysis / adverse effects* Peritonitis / drug therapy*, etiology, metabolism Phosphatidylcholines / administration & dosage, pharmacokinetics* Phosphatidylglycerols / administration & dosage, pharmacokinetics* |
| Grant Support | |
ID/Acronym/Agency:
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5 U01 HD 31313-05/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Drug Combinations; 0/Phosphatidylcholines; 0/Phosphatidylglycerols; 0/liposomal amphotericin B; 1397-89-3/Amphotericin B; 86386-73-4/Fluconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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