| Peritoneal natural killer cells from epithelial ovarian cancer patients show an altered phenotype and bind to the tumour marker MUC16 (CA125). | |
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MedLine Citation:
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PMID: 17617155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ovarian tumour marker MUC16 (CA125) inhibits the cytotoxic responses of human natural killer (NK) cells and down-regulates CD16. Here we show that approximately 10% of the peripheral blood NK cells (PBNK) from the epithelial ovarian cancer (EOC) patients are CD16(-) CD56(br) whereas 40% of the peritoneal fluid NK (PFNK) carry this phenotype, which is usually associated with NK cells from the lymph nodes or human decidua. PBNK from healthy donors exposed to PF show a significant increase in the CD16(-) CD56(br) population. This shift in phenotype is not caused by increased apoptosis of the CD16(+) CD56(dim) cells or selective proliferation of the CD16(-) CD56(br) NK cells. Thus, the terminal differentiation of the CD16(-) CD56(br) NK cells to CD16(+) CD56(dim) subset that occurs during normal NK cell development may actually be a reversible step. A majority of the NK cell receptors (NKp46, NKp44, NKG2D, CD244, CD226, CD158a, CD158b, and CD158e) studied were down-regulated in the PFNK. MUC16 binds selectively to 30-40% of CD16(+) CD56(dim) NK cells in EOC patients indicating that phenotypic alterations in these cells are mediated by tumour-derived soluble factors. Similar to EOC, MUC16 in early pregnancy also binds to NK cells suggesting shared mechanisms of NK cell suppression in feto-maternal tolerance and immune evasion by ovarian cancers. |
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Authors:
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Jennifer A Belisle; Jennifer A A Gubbels; Cara A Raphael; Martine Migneault; Claudine Rancourt; Joseph P Connor; Manish S Patankar |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2007-07-06 |
Journal Detail:
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Title: Immunology Volume: 122 ISSN: 0019-2805 ISO Abbreviation: Immunology Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-10 Completed Date: 2007-12-07 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0374672 Medline TA: Immunology Country: England |
Other Details:
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Languages: eng Pagination: 418-29 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI 53792, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD
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metabolism Antigens, CD56 / metabolism Antigens, Neoplasm / metabolism Apoptosis / immunology Ascitic Fluid / immunology* CA-125 Antigen / metabolism* Cell Proliferation Female Humans Immunophenotyping Killer Cells, Natural / immunology* Membrane Proteins / metabolism* Ovarian Neoplasms / immunology* Pregnancy / immunology Receptors, IgG / metabolism T-Lymphocyte Subsets / immunology Tumor Markers, Biological / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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CA14520/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD56; 0/Antigens, Neoplasm; 0/CA-125 Antigen; 0/FCGR3B protein, human; 0/MUC16 protein, human; 0/Membrane Proteins; 0/Receptors, IgG; 0/Tumor Markers, Biological |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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