| Peritoneal mesothelioma. | |
| | |
MedLine Citation:
|
PMID: 18841478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OPINION STATEMENT: Malignant peritoneal mesothelioma (MPM) is an aggressive neoplasm that rapidly spreads within the confines of the abdominal cavity to involve most accessible peritoneal and omental surfaces. Current treatment options are unsatisfactory, and new approaches are needed. Recent publications have reported improved survival with an intensive loco-regional treatment strategy including cytoreductive surgery (CRS) along with hyperthermic intraperitoneal chemotherapy (HIPEC). We have noted at our institution prolonged survival in selected patients after intensive multimodality treatment. Our most recently reported trial included initial laparatomy with omentectomy, resection of peritoneal implants, and placement of bilateral peritoneal Portacath; repeated courses of intraperitoneal chemotherapy with doxorubicin, cisplatin, and interferon gamma; second-look laparotomy; and intraoperative hyperthermic perfusion with mitomycin and cisplatin, followed by whole abdominal radiation. To date there have been no universally accepted treatments for MPM. Unless referred to a specialty center, patients are routinely treated with pemetrexed and cisplatin which has been shown to increase survival in pleural mesothelioma. |
| | |
Authors:
|
Mary E Hesdorffer; John Chabot; Carolyn DeRosa; Robert Taub |
Related Documents
:
|
21812538 - The unique entity of nodular lymphocyte-predominant hodgkin lymphoma: current approache... 21726488 - Hodgkin's lymphoma. 9259968 - Pleural lavage cytology immediately after thoracotomy and before closure of the thoraci... 8122888 - Intravascular malignant lymphomatosis: amelioration of neurological symptoms with plasm... 2702988 - Factors affecting relapse in node-negative breast cancer. a multivariate analysis inclu... 8434708 - Stage i renal cell carcinoma. a clinicopathologic study of 82 cases. |
Publication Detail:
|
Type: Journal Article; Review Date: 2008-10-08 |
Journal Detail:
|
Title: Current treatment options in oncology Volume: 9 ISSN: 1534-6277 ISO Abbreviation: Curr Treat Options Oncol Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-10-29 Completed Date: 2009-04-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100900946 Medline TA: Curr Treat Options Oncol Country: United States |
Other Details:
|
Languages: eng Pagination: 180-90 Citation Subset: IM |
Affiliation:
|
Mesothelioma Applied Research Foundation, Santa Barbara, CA, USA. mhesdorer@curemeso.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Clinical Trials as Topic Combined Modality Therapy Female Humans Male Medical Oncology / methods Mesothelioma / diagnosis*, therapy Middle Aged Peritoneal Neoplasms / diagnosis*, therapy Pleural Neoplasms / diagnosis*, therapy Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neuropsychological, cognitive, and theoretical considerations for evaluation of bilingual individual...
Next Document: Prediction of tablet film-coating thickness using a rotating plate coating system and NIR spectrosco...