Document Detail

Peritoneal fibrinolytic response to various aspects of laparoscopic surgery: a randomized trial.
MedLine Citation:
PMID:  17054995     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Peritoneal fibrinolysis is important in peritoneal wound healing processes and adhesion formation. The peritoneal fibrinolytic response to laparoscopy is merely unknown. In the present study we investigate the effect of short-term laparoscopy on the peritoneal fibrinolytic response and the influence of intra-abdominal pressure, light intensity and choice of dissection device on this response. METHODS: There were 50 patients scheduled for laparoscopic cholecystectomy randomized in five groups operated with various pressures, light intensities, and dissection devices. Peritoneal biopsies were taken at the beginning and the end of the procedure. Tissue concentrations of tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor type 1 (PAI-1), and the tPA-activity were measured using ELISA techniques. RESULTS: There were no differences in tPA antigen, tPA-activity, uPA antigen, or PAI-1 antigen concentrations in biopsies taken at the beginning compared to samples taken at the end of the operation. Different intra-abdominal pressures, light intensities and the choice dissection device did not affect any of the measured parameters. CONCLUSION: Short-term laparoscopy does not affect the peritoneal fibrinolytic activity. The used intra-abdominal pressure, light intensity and choice of dissection device do not affect peritoneal activity during short-term laparoscopy.
Walter J A Brokelman; Lena Holmdahl; Maria Bergström; Peter Falk; Jean H G Klinkenbijl; Michael M P J Reijnen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2006-10-19
Journal Detail:
Title:  The Journal of surgical research     Volume:  136     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-20     Completed Date:  2007-01-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  309-13     Citation Subset:  IM    
Department of Surgery, Alysis Zorggroep, Locatie Rijnstate, Arnhem, The Netherlands.
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MeSH Terms
Cholecystectomy, Laparoscopic / methods*
Enzyme-Linked Immunosorbent Assay
Middle Aged
Peritoneum / metabolism,  physiology*,  surgery*
Plasminogen Activator Inhibitor 1 / metabolism
Tissue Adhesions / metabolism
Tissue Plasminogen Activator / metabolism
Urokinase-Type Plasminogen Activator / metabolism
Wound Healing*
Reg. No./Substance:
0/Plasminogen Activator Inhibitor 1; EC Plasminogen Activator; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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