| Peritoneal carcinomatosis of colon cancer origin: Highest incidence in women and in patients with right-sided tumors. | |
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MedLine Citation:
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PMID: 21547915 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: : The aim of the study was to evaluate the incidence of peritoneal carcinomatosis (PC) in a prospectively recorded series of colon cancer patients from a defined cohort and to compare clinicopathological characteristics, survival, and TP53 mutation status in primary tumors from patients with and without PC. METHODS: : Clinical data from all colon cancer patients admitted in 1993-2006 were registered prospectively (n = 1,124). In a subset of PC patients, DNA was retrieved from tumor tissue and TP53 mutations analyzed and compared to the mutation status in a historical series. RESULTS: : In the prospective series 10% of female and 7% of male patients had PC (P = 0.05). The PC patients were younger than those without PC (median 4 years, P = 0.002). The incidence of PC was 10.3% and 6.2% (P = 0.03) in patients with primary tumors in the right and left colon, respectively. TP53 was mutated in 57% of the PC patients as compared to 41% in the series of patients without PC (P = 0.05). CONCLUSIONS: : The incidence of PC was higher in right-sided colon cancer and among women. PC patients were younger than non-PC patients, and PC was independently associated with TP53 mutation in the primary tumor. J. Surg. Oncol. © 2011 Wiley-Liss, Inc. |
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Authors:
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Ole Helmer Sjo; Marianne Berg; Marianne Arstad Merok; Matthias Kolberg; Aud Svindland; Ragnhild A Lothe; Arild Nesbakken |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-5 |
Journal Detail:
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Title: Journal of surgical oncology Volume: - ISSN: 1096-9098 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0222643 Medline TA: J Surg Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Department of Gastrointestinal Surgery, Oslo University Hospital, Aker, Oslo, Norway. ole.h.sjo@c2i.net. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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