Document Detail

Peritoneal blood flow during acute experimental pancreatitis. The role of peritoneal exudate.
MedLine Citation:
PMID:  3749809     Owner:  NLM     Status:  MEDLINE    
Peritoneal blood flow is closely related to the pathophysiology of peritoneal exudate during acute pancreatitis. Peritoneal blood flow was determined by the radioactive microsphere method before and 5 h after the beginning of the experiment in 39 piglets with acute hemorrhagic pancreatis, acute edemic pancreatitis, or slowly progressing hypovolemia. The effect of hemorrhagic ascitic fluid was also studied. Cardiac output was determined by thermodilution. Acute experimental hemorrhagic pancreatitis and intraperitoneally injected hemorrhagic ascitic fluid per se caused similar and significant increases in peritoneal blood flow, the increase being unaffected by the correction of the secondary hypovolemia in acute hemorrhagic pancreatitis. Laparotomy combined with duodenotomy also caused a similar increase in peritoneal blood flow. Hypovolemia alone caused only insignificant reduction in peritoneal blood flow. Peritoneal exudate accumulating in the peritoneal cavity during early acute experimental hemorrhagic pancreatitis causes a significant increase in peritoneal blood flow which is unaffected by the correction of the secondary hypovolemia during acute pancreatitis. The inflammatory increase in peritoneal blood flow during acute pancreatitis is evidently a major factor in the accumulation of peritoneal exudate during the disease.
A Lehtola
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  21     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-10-15     Completed Date:  1986-10-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  756-60     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Ascitic Fluid / metabolism*
Hemorrhage / physiopathology
Pancreatitis / physiopathology*
Peritoneum / blood supply*
Regional Blood Flow
Shock / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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