Document Detail


Peritoneal protein transport during the baseline peritoneal equilibration test is an accurate predictor of the outcome of peritoneal dialysis patients.
MedLine Citation:
PMID:  20502046     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Peritoneal protein excretion (PPE) is a potential marker of the outcome in peritoneal dialysis (PD) patients.
METHOD: Observational study of a cohort of 269 patients starting PD in a single unit.
STUDY VARIABLES: total PPE during a baseline peritoneal equilibration test (PET; PET-PPE) and 24-hour PPE. Control variables: essential baseline demographic, laboratory and adequacy markers.
MAIN OUTCOMES: mortality, cardiovascular events and risk of peritonitis. We applied univariate and multivariate strategies of survival analysis.
MAIN RESULTS: PET-PPE sustained a significant, yet limited correlation with 24-hour PPE (r = 0.46, p < 0.0005). At baseline, the main study variables showed an independent correlation with peritoneal transport characteristics (D/P(240') creatinine) and cardiovascular comorbidity. PET-PPE (p < 0.0005, model global χ(2) 59.4) was a more accurate predictor of overall mortality than 24-hour PPE (p = 0.04, χ(2) 50.5). Moreover, PPE during PET, but not 24-hour PPE, was an independent predictor of the risks of cardiovascular and infectious mortality, and of peritonitis.
CONCLUSIONS: Baseline PPE represents a strong independent marker of survival of PD patients. Estimation of PPE during PET is more accurate than 24-hour PPE for this purpose, sustains a definite independent association with cardiovascular and infectious mortality, and shows a significant correlation with the risk of peritonitis.
Authors:
Miguel Pérez-Fontán; Ana Rodríguez-Carmona; Dolores Barreda; Andrés López-Muñiz; Natalia Blanco-Castro; Teresa García-Falcón
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-05-21
Journal Detail:
Title:  Nephron. Clinical practice     Volume:  116     ISSN:  1660-2110     ISO Abbreviation:  Nephron Clin Pract     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-30     Completed Date:  2011-08-30     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101159763     Medline TA:  Nephron Clin Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  c104-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Biological Markers / metabolism
Cardiovascular Diseases / diagnosis,  etiology,  metabolism
Child
Cohort Studies
Diagnostic Tests, Routine / methods,  standards*
Female
Follow-Up Studies
Humans
Male
Middle Aged
Peritoneal Dialysis* / adverse effects
Peritoneum / metabolism*
Peritonitis / diagnosis,  etiology,  metabolism
Predictive Value of Tests
Protein Transport / physiology
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Biological Markers

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