| Peritoneal dialysis as the first-line renal replacement therapy in patients with autosomal dominant polycystic kidney disease. | |
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MedLine Citation:
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PMID: 21458901 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cause of kidney failure. Peritoneal dialysis (PD) often is avoided because of concerns about hernias and peritonitis. STUDY DESIGN: Retrospective matched-cohort study. SETTING & PARTICIPANTS: 42 consecutive patients with ADPKD and 84 nondiabetic patients matched by time of PD therapy initiation. PREDICTORS: ADPKD and comorbid conditions. OUTCOMES: Patient survival, technique survival, peritonitis-free survival; peritonitis rate; abdominal hernias. MEASUREMENTS: Dialysis adequacy and nutritional indexes; rate of decrease in residual renal function; bacteriologic cause of peritonitis. RESULTS: 5-year actuarial survival of the ADPKD and control groups was 71.0% and 69.7% (P = 0.4), whereas technique survival was 51.6% and 37.3%, respectively (P = 0.2). There was no difference in overall rates of peritonitis between the ADPKD and control groups (0.51 vs 0.53 episodes/patient-year; P = 0.3), and the incidence of Gram-negative peritonitis also was similar (0.16 vs 0.14 episodes/patient year; P = 0.5). Abdominal wall hernia was significantly more common in the ADPKD than control group (14 vs 6 cases; P < 0.001), but all patients were able to resume PD therapy after surgical repair. LIMITATIONS: Retrospective study with limited sample size. CONCLUSION: PD is a feasible treatment option for most patients with ADPKD with end-stage renal disease. Although patients with ADPKD have a higher risk of abdominal wall hernia, their overall survival rate and risk of peritonitis are similar to those of other nondiabetic PD patients. |
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Authors:
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Lin Li; Cheuk-Chun Szeto; Bonnie Ching-Ha Kwan; Kai-Ming Chow; Chi-Bon Leung; Philip Kam-Tao Li |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2011-04-02 |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 57 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-23 Completed Date: 2011-07-21 Revised Date: 2011-09-30 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
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Languages: eng Pagination: 903-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Nephrology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China. lilin_616@163.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Male Middle Aged Peritoneal Dialysis* Polycystic Kidney, Autosomal Dominant / mortality, physiopathology, therapy* Renal Replacement Therapy Retrospective Studies Survival Rate / trends Treatment Outcome |
| Comments/Corrections | |
Comment In:
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Am J Kidney Dis. 2011 Sep;58(3):493-4; author reply 494
[PMID:
21856496
]
Am J Kidney Dis. 2011 Sep;58(3):493; author reply 494 [PMID: 21856497 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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