| Peritoneal albumin and protein losses do not predict outcome in peritoneal dialysis patients. | |
| | |
MedLine Citation:
|
PMID: 21071518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND OBJECTIVES: Peritoneal clearance of albumin-unlike the transport of small molecules-is defined by both vascular surface area and size-selective permeability. Few studies have supported a positive correlation between peritoneal albumin loss and mortality. The aim of this study was to investigate whether baseline peritoneal loss and clearance of albumin and other proteins is a risk factor of death in peritoneal dialysis patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: All incident peritoneal dialysis patients in our center during the last 15 years were included. Mass-transfer area coefficient of creatinine and peritoneal clearances of albumin, β₂-microglobulin, α₂-macroglobulin, and immunoglobulin G were calculated during a standard peritoneal permeability analysis. The total amount of albumin loss in the dialysate was also calculated. Overall mortality was studied with an intention-to-treat analysis. RESULTS: Two hundred fifty-seven patients were included. High baseline albumin clearance was associated with fast transport status, the presence of peripheral arterial disease, and a high comorbidity index, whereas C-reactive protein levels did not differ from the patients with low albumin clearance. Age, high comorbidity score, C-reactive protein levels >10 mg/L, and a low serum albumin were associated with mortality. Peritoneal albumin clearances and albumin loss were not associated with death in crude and adjusted analysis. Similarly, peritoneal clearances of immunoglobulin G, α₂-macroglobulin, and β₂-microglobulin were not determinants of survival. CONCLUSIONS: Baseline peritoneal albumin and protein clearances are associated with signs of comorbidity, but this does not have a measurable effect on patient survival. |
| | |
Authors:
|
Olga Balafa; Nynke Halbesma; Dirk G Struijk; Friedo W Dekker; Raymond T Krediet |
Related Documents
:
|
9494008 - Multiple laparotomies for severe intra-abdominal infection. 11680228 - Do paramedics make an effort not to transport at the end of their shifts? 18196468 - Dyspepsia in turkish patients on continuous ambulatory peritoneal dialysis. 3156518 - Surgical aspects of the tenckhoff peritoneal dialysis catheter. a 7 year experience. 20863668 - Clearance of vancomycin during continuous infusion in intensive care unit patients: cor... 20404218 - Filling pressures and collagen metabolism in hypertensive patients with heart failure a... |
Publication Detail:
|
Type: Journal Article Date: 2010-11-11 |
Journal Detail:
|
Title: Clinical journal of the American Society of Nephrology : CJASN Volume: 6 ISSN: 1555-905X ISO Abbreviation: Clin J Am Soc Nephrol Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-03-17 Completed Date: 2011-06-30 Revised Date: 2012-09-19 |
Medline Journal Info:
|
Nlm Unique ID: 101271570 Medline TA: Clin J Am Soc Nephrol Country: United States |
Other Details:
|
Languages: eng Pagination: 561-6 Citation Subset: IM |
Affiliation:
|
Department of Nephrology, Academic Medical Center, Amsterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Blood Proteins / metabolism* Chi-Square Distribution Comorbidity Female Humans Hypoalbuminemia / blood, etiology, mortality Immunoglobulin G / metabolism Kaplan-Meier Estimate Male Middle Aged Netherlands Peritoneal Dialysis / adverse effects, mortality* Peritoneum / metabolism* Permeability Proportional Hazards Models Prospective Studies Risk Assessment Risk Factors Serum Albumin / metabolism* Survival Rate Time Factors Treatment Outcome alpha-Macroglobulins / metabolism beta 2-Microglobulin / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Blood Proteins; 0/Immunoglobulin G; 0/Serum Albumin; 0/alpha-Macroglobulins; 0/beta 2-Microglobulin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Opioid and benzodiazepine use in end-stage renal disease: a systematic review.
Next Document: Association between hemoglobin level and endothelial function in uncomplicated, untreated hypertensi...