| Peripubertal estrogen levels and physical activity affect femur geometry in young adult women. | |
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MedLine Citation:
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PMID: 19575140 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: It is well established that physical activity contributes to bone strength in young females, but less is known about how peripubertal estrogen affects skeletal responses to exercise. METHODS: We used data from 84 participants in the Penn State Young Women's Health Study to test the prediction that young women who (1) had higher E2 levels during the first year after menarche or (2) were more physically active in adolescence will have greater bone strength at the end of adolescence. Subjects were divided into tertiles of physical activity and of E2 level in the first, second, and third postmenarchal years, and femoral strength was calculated from dual-energy X-ray absorptiometry scans of the proximal femur using hip structure analysis. RESULTS: At age 17, subjects with the highest E2 levels in year 1 after menarche had 5-14% greater strength in the narrow neck and intertrochanteric region, and the most active subjects had 10-11% greater strength in the femoral narrow neck vs. less active girls. CONCLUSIONS: This study suggests that both physical activity and peripubertal estrogen have important influences on young adult bone strength and that hormone levels may be mediators of human osteogenic responses to exercise. |
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Authors:
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M J Devlin; C M Stetter; H-M Lin; T J Beck; R S Legro; M A Petit; D E Lieberman; T Lloyd |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-07-03 |
Journal Detail:
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Title: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Volume: 21 ISSN: 1433-2965 ISO Abbreviation: Osteoporos Int Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2011-01-19 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 9100105 Medline TA: Osteoporos Int Country: England |
Other Details:
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Languages: eng Pagination: 609-17 Citation Subset: IM |
Affiliation:
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Department of Anthropology, Harvard University, Cambridge, MA 02138, USA. mdevlin1@bidmc.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Calcium / urine Estradiol / physiology, urine* Female Femur Neck / growth & development, physiology* Humans Longitudinal Studies Menarche / physiology Motor Activity / physiology* Puberty / physiology* Vitamin D / administration & dosage Vitamins / administration & dosage |
| Grant Support | |
ID/Acronym/Agency:
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K23 AR049040-01A1/AR/NIAMS NIH HHS; K23 AR49040-01A1/AR/NIAMS NIH HHS; M01 RR010732-05/RR/NCRR NIH HHS; M01-RR-10732/RR/NCRR NIH HHS; R01 HD025973-10/HD/NICHD NIH HHS; R01 HD25973/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Vitamins; 1406-16-2/Vitamin D; 50-28-2/Estradiol; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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