| Periprocedural drug therapy in carotid artery stenting: the need for more evidence. | |
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MedLine Citation:
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PMID: 19344586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carotid artery stenting (CAS) is a widely accepted alternative for patients at high risk for carotid endarterectomy (CEA). However, the role, indications, and evidence for many pharmacologic agents that are used adjunctively in the periprocedural setting have not been established. Several drugs are commonly used before, during, and after CAS, but their uses have not been standardized. Large prospective cohort studies with good validity or randomized trials are needed to demonstrate efficacy, predict outcome, and determine the optimal use of these medications in patients undergoing CAS to improve patient care and obtain optimal outcomes. Several conclusions can be made: (1) dual-antiplatelet therapy (aspirin and clopidogrel) is commonly used for CAS; (2) the most commonly used regimen is aspirin 325 mg and clopidogrel 75 mg per day, but the optimal time of therapy is unknown; and (3) the dose and regimen of other agents used for CAS are not established. |
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Authors:
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David Gortler; Felix J V Schlösser; Bart E Muhs; Michael A Nelson; Alan Dardik |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Vascular Volume: 16 ISSN: 1708-5381 ISO Abbreviation: Vascular Publication Date: 2008 Nov-Dec |
Date Detail:
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Created Date: 2009-04-06 Completed Date: 2009-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101196722 Medline TA: Vascular Country: Canada |
Other Details:
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Languages: eng Pagination: 303-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520-8089, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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therapeutic use* Aspirin / therapeutic use Atropine / therapeutic use Carotid Arteries / surgery* Carotid Stenosis / surgery* Heparin / therapeutic use Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Platelet Aggregation Inhibitors / therapeutic use* Premedication / methods* Stents* Ticlopidine / analogs & derivatives, therapeutic use Warfarin / therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
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HL079927/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 51-55-8/Atropine; 55142-85-3/Ticlopidine; 81-81-2/Warfarin; 9005-49-6/Heparin; 90055-48-4/clopidogrel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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