| Periprocedural MRI perfusion imaging to assess and monitor the hemodynamic impact of intracranial angioplasty and stenting for symptomatic atherosclerotic stenosis. | |
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MedLine Citation:
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PMID: 20005721 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We aimed to assess the clinical value of MRI perfusion imaging in the periprocedural management of intracranial atherosclerosis, analyzing if changes in mean transit time (MTT), cerebral blood volume (CBV) and cerebral blood flow (CBF) correlated with angiographic outcomes. Pre-procedural and post-procedural MRI perfusion was performed on six patients who underwent angioplasty and/or stenting for symptomatic intracranial atherosclerosis. MTT, CBV and CBF were analyzed and graded. In 83% of patients, perfusion imaging correlated with angiographic outcomes. Perfusion parameters improved to normal in two patients. Two showed marked improvement and one showed mild improvement. In one patient, the results of the post-procedural MRI perfusion prompted an angiogram, which confirmed stent occlusion. Semi-quantitative scores of MTT and CBF changed over time (p=0.05, p=0.03) whereas CBV did not change significantly (p>0.05). We conclude that MRI perfusion appears a promising technique for analyzing the impact of intracranial stenosis on cerebral hemodynamics before and after treatment. |
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Authors:
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Bernard R Bendok; Arun K Sherma; Ziad A Hage; Sunit Das; Andrew M Naidech; Daniel L Surdell; Joseph G Adel; Ali Shaibani; H Hunt Batjer; Timothy J Carroll; Mathew Walker |
Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2009-12-14 |
Journal Detail:
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Title: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Volume: 17 ISSN: 1532-2653 ISO Abbreviation: J Clin Neurosci Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-06-07 Revised Date: 2011-01-21 |
Medline Journal Info:
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Nlm Unique ID: 9433352 Medline TA: J Clin Neurosci Country: Scotland |
Other Details:
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Languages: eng Pagination: 54-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Neurosurgery, Feinberg School of Medicine, Northwestern University, 676 North St Clair Street, Suite 2210, Chicago, Illinois 60611, USA. bbendok@nmff.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty / adverse effects, methods Cerebral Arteries / pathology*, physiopathology Cerebrovascular Circulation / physiology* Female Hemodynamics Humans Intracranial Arteriosclerosis / pathology*, physiopathology, therapy Magnetic Resonance Angiography / methods* Male Monitoring, Intraoperative / methods* Outcome Assessment (Health Care) / methods* Predictive Value of Tests Retrospective Studies Sensitivity and Specificity Stents Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS049395-04/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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