| Peripodial cells regulate proliferation and patterning of Drosophila imaginal discs. | |
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MedLine Citation:
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PMID: 11057906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cells employ a diverse array of signaling mechanisms to establish spatial patterns during development. Nowhere is this better understood than in Drosophila, where the limbs and eyes arise from discrete epithelial sacs called imaginal discs. Molecular-genetic analyses of pattern formation have generally treated discs as single epithelial sheets. Anatomically, however, discs comprise a columnar cell monolayer covered by a squamous epithelium known as the peripodial membrane. Here we demonstrate that during development, peripodial cells signal to disc columnar cells via microtubule-based apical extensions. Ablation and targeted gene misexpression experiments demonstrate that peripodial cell signaling contributes to growth control and pattern formation in the eye and wing primordia. These findings challenge the traditional view of discs as monolayers and provide foundational evidence for peripodial cell function in Drosophila appendage development. |
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Authors:
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M C Gibson; G Schubiger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell Volume: 103 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-11-15 Completed Date: 2000-11-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 343-50 Citation Subset: IM |
Affiliation:
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Department of Zoology, University of Washington, Seattle 98195, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport Body Patterning* Cell Surface Extensions / metabolism Drosophila / cytology, embryology* Drosophila Proteins Embryonic Induction* Epithelial Cells* Eye / anatomy & histology, embryology Microtubule-Associated Proteins / metabolism Microtubules / metabolism Models, Biological Molecular Motor Proteins / metabolism Photoreceptor Cells, Invertebrate / anatomy & histology, embryology Wing / embryology |
| Grant Support | |
ID/Acronym/Agency:
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GM58282/GM/NIGMS NIH HHS; T32 GM07270/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/Glued protein, Drosophila; 0/Microtubule-Associated Proteins; 0/Molecular Motor Proteins |
| Comments/Corrections | |
Comment In:
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Cell. 2000 Oct 13;103(2):189-92
[PMID:
11057892
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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