Document Detail

Peripherally administered somatostatin reduces feeding by a vagal mediated mechanism.
MedLine Citation:
PMID:  6125953     Owner:  NLM     Status:  MEDLINE    
Somatostatin (SS) is considered to be an important regulator of nutrient homeostasis. As such, we felt it would be of use to study in detail its effects on feeding. Intraperitoneal administration of SS (10 microgram/kg) reduces spontaneous nocturnal feeding (3.6 +/- 0.6 g/2 hr vs 1.6 +/- 0.5 g/2 hr, p less than 0.025). In a separate study we found that SS also reduced spontaneous feeding in sham operated animals, but not in vagotomized animals (1.2 +/- 0.7 g/2 hr vs 3.8 +/- g/2 hr, p less than 0.05). SS inhibited stress (tail-pinch) induced eating at 10 and 1, but not 0.1 microgram/kg and also inhibited insulin (10 U/kg) failed to suppress water intake or ingestion of a 2% sucrose solution suggesting that somatostatin does not suppress feeding by a generalized disruption of behavior or due to the aversiveness of SS. However, food intake also was not suppressed following food deprivation, suggesting a possible aversive effect of SS. We conclude that somatostatin may play a role as one of the physiological signals involved in short-term appetite regulation. Like CCK, the effects of SS would appear to be mediated through the vagus.
A S Levine; J E Morley
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  16     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-10-12     Completed Date:  1982-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  897-902     Citation Subset:  IM    
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MeSH Terms
Cholecystokinin / pharmacology
Drinking / drug effects
Eating / drug effects*
Endorphins / pharmacology
Food Deprivation
Insulin / pharmacology
Muscimol / pharmacology
Norepinephrine / pharmacology
Peptide Fragments / pharmacology
Rats, Inbred Strains
Satiation / drug effects
Somatostatin / pharmacology*
Thyrotropin-Releasing Hormone / pharmacology
Vagus Nerve / drug effects*
Reg. No./Substance:
0/Endorphins; 0/Peptide Fragments; 11061-68-0/Insulin; 24305-27-9/Thyrotropin-Releasing Hormone; 25126-32-3/Sincalide; 2763-96-4/Muscimol; 51-41-2/Norepinephrine; 51110-01-1/Somatostatin; 72957-38-1/dynorphin (1-13); 74913-18-1/Dynorphins; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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