Document Detail


Peripheral vasodilatation following 1,1,1-trichloroethane inhalation: peripheral vessels as a site of action.
MedLine Citation:
PMID:  6497446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of 1,1,1-trichloroethane (1,1,1-TCE) inhalation on total peripheral vascular resistance and the possibility of the peripheral vessels being a site of action for 1,1,1-TCE were investigated in anesthetized dogs. In acute inhalation experiments, a decrease in total peripheral vascular resistance was observed following inhalation of 1,1,1-TCE concentrations sufficient to induce systemic hypotension. The threshold concentration of 1,1,1-TCE required to produce a decrease in perfusion pressure of the isolated hindlimb was approximately 0.4-0.5% in inspired air. A dose-response relationship between the decrease in perfusion pressure and 1,1,1-TCE concentration, which exceeded the threshold level, was observed. It is suggested that the decrease in total peripheral vascular resistance is related to systemic hypotension following 1,1,1-TCE inhalation; further, this vasodilator effect may be induced in the peripheral vessels, which is one of the sites where 1,1,1-TCE acts.
Authors:
H Kobayashi; T Hobara; T Kawamoto; T Sakai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of environmental health     Volume:  39     ISSN:  0003-9896     ISO Abbreviation:  Arch. Environ. Health     Publication Date:    1984 Jul-Aug
Date Detail:
Created Date:  1984-11-26     Completed Date:  1984-11-26     Revised Date:  2013-01-24    
Medline Journal Info:
Nlm Unique ID:  0212627     Medline TA:  Arch Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  294-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Dogs
Hindlimb / blood supply*
Humans
Hydrocarbons, Chlorinated / pharmacology*
Hypotension / chemically induced
Male
Perfusion
Trichloroethanes / pharmacology*
Vascular Resistance / drug effects
Vasodilation / drug effects*
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Hydrocarbons, Chlorinated; 0/Trichloroethanes; 0/Vasodilator Agents; 113C650IR1/1,1,1-trichloroethane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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