Document Detail

Peripheral vascular occlusions leading to gangrene and amputations in antiphospholipid antibody positive patients.
MedLine Citation:
PMID:  17894017     Owner:  NLM     Status:  MEDLINE    
Twenty-one cases from several medical centers (Brazil, Italy, Serbia, South Africa, Israel, and the United Kingdom) with severe peripheral vascular disease progressing to amputations of limbs/digits, all of whom tested positive for antiphospholipid antibodies, are documented. The patients were suffering from either systemic lupus erythematosus, discoid LE, "primary" antiphospholipid syndrome (PAPS), "lupus-like" disease, undifferentiated connective tissue disease. A high frequency of livedo reticularis preceding the arterial occlusions in our series of patients who subsequently progressed to ischemic necrosis and amputation of limbs/digits was noted. Five of the 10 patients, in whom histopathological studies had been performed, demonstrated the typical vasculopathy seen with the antiphospholipid syndrome ("APS vasculopathy"). Complicating vasculitis was present in seven of the patients. Five of the patients developed severe peripheral vascular disease during the course of the catastrophic antiphospholipid (Asherson's) syndrome.
Ronald A Asherson; Ricard Cervera; Yehuda Shoenfeld
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1108     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-09-25     Completed Date:  2007-10-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  515-29     Citation Subset:  IM    
Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.
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MeSH Terms
Antibodies, Antiphospholipid / blood
Antiphospholipid Syndrome / complications*,  pathology,  surgery
Catastrophic Illness
Connective Tissue Diseases / complications*
Extremities / pathology,  surgery
Fingers / pathology
Gangrene / etiology*,  surgery
General Surgery
Middle Aged
Peripheral Vascular Diseases / etiology*,  surgery
Toes / pathology,  surgery
Reg. No./Substance:
0/Antibodies, Antiphospholipid

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