| Peripheral vascular occlusions leading to gangrene and amputations in antiphospholipid antibody positive patients. | |
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MedLine Citation:
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PMID: 17894017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-one cases from several medical centers (Brazil, Italy, Serbia, South Africa, Israel, and the United Kingdom) with severe peripheral vascular disease progressing to amputations of limbs/digits, all of whom tested positive for antiphospholipid antibodies, are documented. The patients were suffering from either systemic lupus erythematosus, discoid LE, "primary" antiphospholipid syndrome (PAPS), "lupus-like" disease, undifferentiated connective tissue disease. A high frequency of livedo reticularis preceding the arterial occlusions in our series of patients who subsequently progressed to ischemic necrosis and amputation of limbs/digits was noted. Five of the 10 patients, in whom histopathological studies had been performed, demonstrated the typical vasculopathy seen with the antiphospholipid syndrome ("APS vasculopathy"). Complicating vasculitis was present in seven of the patients. Five of the patients developed severe peripheral vascular disease during the course of the catastrophic antiphospholipid (Asherson's) syndrome. |
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Authors:
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Ronald A Asherson; Ricard Cervera; Yehuda Shoenfeld |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1108 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-09-25 Completed Date: 2007-10-30 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 515-29 Citation Subset: IM |
Affiliation:
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Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa. ashron@icon.co.za |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amputation* Antibodies, Antiphospholipid / blood Antiphospholipid Syndrome / complications*, pathology, surgery Catastrophic Illness Connective Tissue Diseases / complications* Extremities / pathology, surgery Female Fingers / pathology Gangrene / etiology*, surgery General Surgery Humans Male Middle Aged Peripheral Vascular Diseases / etiology*, surgery Toes / pathology, surgery |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antiphospholipid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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