Document Detail

Peripheral pulsed electromagnetic fields may reduce the placebo effect in migraine patients that do not respond to the sham intervention in a randomized, placebo-controlled, double-blind, cross-over clinical trial.
MedLine Citation:
PMID:  22305246     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: The purpose of the study was to evaluate the effect of the pulsed electromagnetic fields (PEMF) and its possible modulation of the placebo effect in migraine.
DESIGN: Placebo-controlled, randomized, double-blind, cross-over clinical trial.
SETTING: Government third level hospital.
INTERVENTIONS: Patients with migraine were included. PEMF were applied to the wrist with a bracelet.
MAIN OUTCOME MEASURES: Frequency and intensity of the migraine attacks at baseline and during treatment were recorded. Also, we valuated the possible influence of gender and the presence of aura in the PEMF and placebo responses.
RESULTS: Eighteen patients (fifteen women, 30±2 years old) were included. Migraine frequency and intensity was reduced with both PEMF and placebo to a similar extent in the whole population. However, in responders to placebo, migraine intensity was reduced to a median of 100% with the placebo and to 60% with the PEMF, while in non-responders there was only a slight effect of both treatments. Our results do not suggest an influence of gender or presence of aura in the outcomes.
CONCLUSIONS: Treatment with PEMF may not alter either migraine intensity or frequency compared to baseline, but may reduce the response to placebo in migraine patients.
Daniel San-Juan; Ana Aurora L Pon; Fernando Z Pohls; Juan de Dios Del Castillo-Calcáneo; Iván Pérez-Neri; Camilo Ríos
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Publication Detail:
Type:  Journal Article     Date:  2011-10-15
Journal Detail:
Title:  Complementary therapies in medicine     Volume:  20     ISSN:  1873-6963     ISO Abbreviation:  Complement Ther Med     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9308777     Medline TA:  Complement Ther Med     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  31-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Department of Neurophysiology, National Institute of Neurology and Neurosurgery, Insurgentes Sur 3877, La Fama, Tlalpan, Mexico City 14269, Mexico; Centro Neurológico ABC, Centro Médico ABC, México City, Mexico.
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