Document Detail


Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival.
MedLine Citation:
PMID:  21182197     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Little is known about the molecular factors that are altered in remitting bipolar disorder (BD) patients. We carried out proteome profiling of peripheral blood mononuclear cells (PBMCs) and serum from BD patients who were not experiencing mania or major depression (euthymia) compared to matched healthy controls using liquid chromatography-mass spectrometry (LC-MS(E) ) and Multi-Analyte Profiling (Human Map(®) ) platforms. This resulted in the identification of approximately 60 differentially expressed molecules involved predominantly in cell death/survival pathways. In PBMCs, this was manifested in cytoskeletal and stress response-associated proteins, whereas most serum analytes were associated with the inflammatory response. The predicted effect of serum analytes on physiological systems was tested by treating PBMCs with serum obtained from the same patients, resulting in reduced cellular survival. These preliminary results suggest that BD patients carry a peripheral fingerprint that has detrimental effects on cell function and that could be used to distinguish BD patients from healthy controls despite being in a remission phase. It is hoped that additional studies of BD patients in the manic and depressed stages could lead to the identification of a molecular fingerprint that could be used for predicting episodic switching and for guiding treatment strategies.
Authors:
Marlis Herberth; Dagmar Koethe; Yishai Levin; Emanuel Schwarz; Natalia D Krzyszton; Stephanie Schoeffmann; Hermelindis Ruh; Hassan Rahmoune; Laura Kranaster; Torsten Schoenborn; Markus F Leweke; Paul C Guest; Sabine Bahn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-06
Journal Detail:
Title:  Proteomics     Volume:  11     ISSN:  1615-9861     ISO Abbreviation:  Proteomics     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101092707     Medline TA:  Proteomics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  94-105     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, UK.
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