Document Detail

Peripheral neuropathy in lead-intoxicated sickle cell patients.
MedLine Citation:
PMID:  220532     Owner:  NLM     Status:  MEDLINE    
Peripheral neuropathy and hypertension caused by lead intoxication are reported in two children with sickle cell anemia. One child had generalized weakness in the initial occurrence and distal paralysis during a relapse two years later. The second child had foot and wrist drop. Both had slow peripheral nerve conduction velocities during the episodes. Chelation therapy was successful and resulted in a return of strength (over a period of several months) and a normalization of the blood pressures. Children with sickle cell anemia who are subjected to lead intoxication appear to be predisposed to peripheral nerve damage.
C E Imbus; J Warner; E Smith; C H Pegelow; J P Allen; D R Powars
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  1     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:    1978 Mar-Apr
Date Detail:
Created Date:  1979-07-16     Completed Date:  1979-07-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  168-71     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anemia, Sickle Cell / complications*
Child, Preschool
Edetic Acid / therapeutic use
Hypertension / chemically induced*
Lead Poisoning / complications*,  drug therapy
Paralysis / chemically induced
Peripheral Nervous System Diseases / chemically induced*
Reg. No./Substance:
60-00-4/Edetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Sural nerve conduction study in the rat: a new technique for studying experimental neuropathies.
Next Document:  Lumbar plexus neuropathy resulting from retroperitoneal hemorrhage.