Document Detail

Peripheral neuropathy during alpha-interferon therapy in a child with Hodgkin's disease.
MedLine Citation:
PMID:  10599097     Owner:  NLM     Status:  MEDLINE    
Peripheral neuropathy is one of the rarely reported neurological complications of interferon therapy. The authors report such a case in a 15-year-old boy during alpha-interferon therapy for Hodgkin's disease. He received alpha-interferon at a dose of 1.8 million units/day 5 times a week by subcutaneous injections as adjuvant immunotherapy post autologous stem cell transplant. Twenty months after the initiation of therapy, he complained of severe pain in his lower distal extremities. Neurological examination revealed the absence of deep tendon reflexes. A nerve conduction study showed a sensorial, polyneuropathic involvement in the lower extremities. Within 4 weeks after the stopping of interferon, his pain improved, and recovery was also seen by nerve conduction studies. Symptoms reappeared at the resumption of interferon treatment. This study suggests that peripheral neuropathy may rarely occur in patients given long-term interferon treatment at high cumulative dosage.
S Emir; T Kutluk; K W Chan; B Yalçin; K Varli; M Büyükpamukçu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric hematology and oncology     Volume:  16     ISSN:  0888-0018     ISO Abbreviation:  Pediatr Hematol Oncol     Publication Date:    1999 Nov-Dec
Date Detail:
Created Date:  2000-02-16     Completed Date:  2000-02-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8700164     Medline TA:  Pediatr Hematol Oncol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  557-60     Citation Subset:  IM    
Department of Pediatric Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
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MeSH Terms
Hodgkin Disease / drug therapy*
Interferon-alpha / adverse effects*,  therapeutic use
Peripheral Nervous System Diseases / chemically induced*
Reg. No./Substance:
Comment In:
Pediatr Hematol Oncol. 1999 Nov-Dec;16(6):499-500   [PMID:  10599088 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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