| Peripheral neuropathy associated with primary Sjögren's syndrome. | |
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MedLine Citation:
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PMID: 8057125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical and electrophysiological signs of peripheral neuropathy were found in 10 of 46 patients (21.7%) with primary Sjögren's syndrome, symmetric polyneuropathy in seven (mainly sensory in five, mainly autonomic in two), sensory neuronopathy in two patients, and mononeuropathy multiplex in one patient. Peripheral neuropathy was the presenting manifestation in five patients (10.9%). Onset of the disease after 50 years was significantly more common in the polyneuropathy group (six of seven) than in non-neuropathic patients with primary Sjögren's syndrome (14 of 36; p = 0.034). No other difference in clinical or laboratory variables between neuropathic and non-neuropathic patients with primary Sjogren's syndrome was found. Neurophysiological study showed variable findings predominantly suggesting an axonopathy. Nerve biopsy showed moderate remyelination and regeneration in four patients, and fibre loss, mainly of large size, in three. Necrotising vasculitis was not seen but alterations of the endoneurial microvessels were prominent. |
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Authors:
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F Gemignani; A Marbini; G Pavesi; S Di Vittorio; P Manganelli; G Cenacchi; D Mancia |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 57 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1994-09-09 Completed Date: 1994-09-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 983-6 Citation Subset: IM |
Affiliation:
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Institute of Neurology, University of Parma, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Biopsy Electrophysiology Female Humans Male Middle Aged Nerve Regeneration* Peripheral Nervous System Diseases / diagnosis, epidemiology, etiology*, physiopathology Prevalence Sjogren's Syndrome / complications* Time Factors |
| Comments/Corrections | |
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