Document Detail

Peripheral neuropathy associated with acquired immunodeficiency syndrome. Prevalence and clinical features from a population-based survey.
MedLine Citation:
PMID:  2843154     Owner:  NLM     Status:  MEDLINE    
We prospectively studied 40 hospitalized patients who had well-established diagnoses of acquired immunodeficiency syndrome. Patients with confounding risk factors for neuropathy were excluded; none of the study patients had known vitamin deficiency, alcoholism, or any metabolic, drug, or toxic factor. Clinical and electrophysiologic evidence of a distal symmetric polyneuropathy was found in 35% (13/37) of the patients. Symptoms and signs of neuropathy were usually mild, and painful dysesthesias were uncommon. Amplitude reduction of sural nerve action potentials distinguished all patients with from those without clinical neuropathy. Results of other electrophysiologic studies of sural, peroneal, and median nerves were typically normal. These results provide evidence of distal axonal degeneration. Neuropathy occurred only in patients with systemic illness longer than five months' duration. When compared with patients without neuropathy, these patients had more severe weight loss and a higher incidence of clinical dementia. Follow-up evaluation showed no evidence of clinical progression over a six-month period. The pathogenesis of this common distal axonal polyneuropathy is unknown and warrants further investigation.
Y T So; D M Holtzman; D I Abrams; R K Olney
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  45     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-09-29     Completed Date:  1988-09-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  945-8     Citation Subset:  AIM; IM; X    
Department of Neurology, University of California, San Francisco 94143.
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications*,  mortality
Action Potentials
Dementia / complications
Follow-Up Studies
Neural Conduction
Peripheral Nervous System Diseases / complications*,  physiopathology
Prospective Studies
Sural Nerve

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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