Document Detail

Peripheral neuropathy: assessment of proximal nerve integrity by diffusion tensor imaging.
MedLine Citation:
PMID:  23532987     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: We investigated the utility of diffusion tensor imaging (DTI) for detecting neuropathic changes in proximal nerve segments in patients with peripheral neuropathy.
METHODS: Twenty-one individuals with (n = 11) and without (n = 10) peripheral neuropathy underwent DTI of a defined sciatic nerve segment. Patients and controls were evaluated by clinical examination and nerve conduction studies at baseline and 6 months after the initial DTI scan.
RESULTS: The mean fractional anisotropy (FA) value was significantly lower in sciatic nerves from patients with peripheral neuropathy as compared with controls. Sciatic nerve FA values correlated with clinical disability scores and electrophysiological parameters of axonal damage at baseline and 6 months after MRI scan.
CONCLUSIONS: DTI-derived FA values are a sensitive measure to discriminate healthy from functionally impaired human sciatic nerve segments. DTI of proximal nerve segments may be useful for estimating the proximal axonal degeneration burden in patients with peripheral neuropathies.
Christian Mathys; Joel Aissa; Gerd Meyer Zu Hörste; Dorothea C Reichelt; Gerald Antoch; Bernd Turowski; Hans-Peter Hartung; Kazim A Sheikh; Helmar C Lehmann
Related Documents :
25038607 - Trigeminal nerve asymmetry in classic trigeminal neuralgia - pretreatment volumetry and...
23531437 - Sciatic nerve regeneration is not inhibited by anti-ngf antibody treatment in the adult...
23449097 - Endoscopic detection of compressing fascial bands around the ulnar nerve within the fcu.
21636567 - Time course of isotonic shortening and the underlying contraction mechanism in airway s...
24006347 - A three-dimensional musculoskeletal model of the chimpanzee (pan troglodytes) pelvis an...
7850877 - Muscle function and origin of pain in fibromyalgia.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-10-04
Journal Detail:
Title:  Muscle & nerve     Volume:  48     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-11-22     Completed Date:  2014-01-13     Revised Date:  2014-03-03    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  889-96     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diffusion Tensor Imaging*
Middle Aged
Neural Conduction / physiology
Neurologic Examination
Peripheral Nervous System Diseases / diagnosis*,  physiopathology*
ROC Curve
Sciatic Nerve / pathology,  physiopathology
Statistics, Nonparametric
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Peripheral CD4(+) T-cell tolerance is induced in vivo by rare antigen-bearing B cells in follicular,...
Next Document:  Preferring thin people does not imply derogating fat people. A rasch analysis of the implicit weight...