Document Detail

Peripheral neuropathy: assessment of proximal nerve integrity by diffusion tensor imaging.
MedLine Citation:
PMID:  23532987     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: We investigated the utility of diffusion tensor imaging (DTI) for detecting neuropathic changes in proximal nerve segments in patients with peripheral neuropathy.
METHODS: Twenty-one individuals with (n = 11) and without (n = 10) peripheral neuropathy underwent DTI of a defined sciatic nerve segment. Patients and controls were evaluated by clinical examination and nerve conduction studies at baseline and 6 months after the initial DTI scan.
RESULTS: The mean fractional anisotropy (FA) value was significantly lower in sciatic nerves from patients with peripheral neuropathy as compared with controls. Sciatic nerve FA values correlated with clinical disability scores and electrophysiological parameters of axonal damage at baseline and 6 months after MRI scan.
CONCLUSIONS: DTI-derived FA values are a sensitive measure to discriminate healthy from functionally impaired human sciatic nerve segments. DTI of proximal nerve segments may be useful for estimating the proximal axonal degeneration burden in patients with peripheral neuropathies.
Christian Mathys; Joel Aissa; Gerd Meyer Zu Hörste; Dorothea C Reichelt; Gerald Antoch; Bernd Turowski; Hans-Peter Hartung; Kazim A Sheikh; Helmar C Lehmann
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-10-04
Journal Detail:
Title:  Muscle & nerve     Volume:  48     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-11-22     Completed Date:  2014-01-13     Revised Date:  2014-03-03    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  889-96     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
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MeSH Terms
Diffusion Tensor Imaging*
Middle Aged
Neural Conduction / physiology
Neurologic Examination
Peripheral Nervous System Diseases / diagnosis*,  physiopathology*
ROC Curve
Sciatic Nerve / pathology,  physiopathology
Statistics, Nonparametric
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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