Document Detail

Peripheral neuropathology of the upper airway in obstructive sleep apnea syndrome.
MedLine Citation:
PMID:  22902356     Owner:  NLM     Status:  Publisher    
Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder that leads to significant morbidity and mortality without adequate treatment. Though much emphasis on the pathogenesis of OSAS has been placed on a narrow upper airway space and associated muscular factors, possible neuropathy of the upper airway has not been fully elucidated. Increasing peer reviewed evidence suggests involvement of neurologic lesions of the upper airway in OSAS patients. In this article, we review the etiology and pathophysiology of OSAS, the evidence and possible mechanisms leading to upper airway neuropathy, and the relationship between upper airway neuropathy and OSAS. Further studies should focus on the long term effects of the upper airway neuropathy as related to the duration and severity of snoring and or apnea, and also on the potential methods of prevention and management of the neuropathy in sleep disordered breathing.
Yi-Ju Tsai; Kannan Ramar; Yao-Jen Liang; Po-Han Chiu; Nelson Powell; Chao-Yun Chi; Tzu-Chen Lung; Wesley Wen-Yang Lin; Po-Jung Tseng; Ming-Ying Wu; Kuan-Chiao Chien; Edward M Weaver; Fei-Peng Lee; Chia-Mo Lin; Kuang-Chao Chen; Rayleigh Ping-Ying Chiang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-16
Journal Detail:
Title:  Sleep medicine reviews     Volume:  -     ISSN:  1532-2955     ISO Abbreviation:  Sleep Med Rev     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9804678     Medline TA:  Sleep Med Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
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