Document Detail

Peripheral neuroglial death induced by cisplatin administration in newborn rats.
MedLine Citation:
PMID:  11201074     Owner:  NLM     Status:  MEDLINE    
To determine the target of cytotoxicity of cisplatin (CDDP), we injected newborn rats with 2 mg/kg CDDP and examined the trigeminal ganglion for possible cell death. A nick translation method for DNA fragmentation revealed CDDP-induced glial cell death. DNA fragmentation was detected in both Schwann cells and satellite cells. Satellite cell death was observed as early as 0.5 day after injection, most frequent at 1-3 days and subsided thereafter. The incidence of neuronal death was very low and comparable to that observed in vehicle control rats. CDDP has selective toxicity to peripheral glial cells, though the damage did not culminate in cell death in adults. The glial toxicity may contribute to clinical symptoms of CDDP neuropathy.
T Sugimoto; A Takeyama; M Fujita; H Ichikawa; T Takano-Yamamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroreport     Volume:  12     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-30     Completed Date:  2001-03-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  137-40     Citation Subset:  IM    
Department of Oral Anatomy, Okayama University Dental School, Japan.
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MeSH Terms
Animals, Newborn
Antineoplastic Agents / pharmacology*
Cell Death / drug effects,  physiology
Cisplatin / pharmacology*
DNA Fragmentation
Neuroglia / drug effects,  pathology
Neurons / drug effects*
Oligodendroglia / drug effects*,  pathology
Rats, Sprague-Dawley
Schwann Cells / drug effects*,  pathology
Trigeminal Ganglion / drug effects,  pathology
Reg. No./Substance:
0/Antineoplastic Agents; 15663-27-1/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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