Document Detail

Peripheral nervous system involvement in multiple sclerosis.
MedLine Citation:
PMID:  20629712     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate possible peripheral nervous system (PNS) affection in patients with multiple sclerosis (MS) by standard nerve conduction velocity (SNC) and pain-related evoked potentials (PREP), a novel electrophysiological method for diagnosing small fibre neuropathy.
BACKGROUND: Former neuropathological and electrophysiological studies demonstrated subtle PNS affection in MS, but routine measurements are mostly normal. Small fibre polyneuropathy is associated with several autoimmune diseases but has not been investigated in MS yet.
DESIGN/METHODS: Fifty-four patients with MS (43 relapsing-remitting, 11 secondary progressive MS) underwent SNC of the tibial, sural and peroneal nerve. Twenty-one patients additionally underwent PREP.
RESULTS: SNC abnormalities were observed in 29.6% of all patients and 14.2% of all nerves examined No abnormalities on PREP were found.
CONCLUSIONS/RELEVANCE: We demonstrated subtle alterations on routine electrophysiological measurements in patients with MS without hints for small fibre pathology.
K Gartzen; Z Katzarava; H-C Diener; N Putzki
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  18     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-15     Completed Date:  2012-03-16     Revised Date:  2012-09-10    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  789-91     Citation Subset:  IM    
Copyright Information:
© 2010 The Author(s). European Journal of Neurology © 2010 EFNS.
Department of Neurology, University Clinic Essen, University of Duisburg-Essen, Essen, Germany.
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MeSH Terms
Comorbidity / trends
Electrodiagnosis / methods*
Middle Aged
Multiple Sclerosis / diagnosis,  epidemiology*,  physiopathology*
Peripheral Nerves / physiopathology*
Peripheral Nervous System Diseases / diagnosis,  epidemiology*,  physiopathology*

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