| Peripheral nervous system involvement in multiple sclerosis. | |
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MedLine Citation:
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PMID: 20629712 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: To investigate possible peripheral nervous system (PNS) affection in patients with multiple sclerosis (MS) by standard nerve conduction velocity (SNC) and pain-related evoked potentials (PREP), a novel electrophysiological method for diagnosing small fibre neuropathy. Background: Former neuropathological and electrophysiological studies demonstrated subtle PNS affection in MS, but routine measurements are mostly normal. Small fibre polyneuropathy is associated with several autoimmune diseases but has not been investigated in MS yet. Design/Methods: Fifty-four patients with MS (43 relapsing-remitting, 11 secondary progressive MS) underwent SNC of the tibial, sural and peroneal nerve. Twenty-one patients additionally underwent PREP. Results: SNC abnormalities were observed in 29.6% of all patients and 14.2% of all nerves examined No abnormalities on PREP were found. Conclusions/Relevance: We demonstrated subtle alterations on routine electrophysiological measurements in patients with MS without hints for small fibre pathology. |
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Authors:
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K Gartzen; Z Katzarava; H-C Diener; N Putzki |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 18 ISSN: 1468-1331 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England |
Other Details:
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Languages: eng Pagination: 789-91 Citation Subset: IM |
Copyright Information:
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© 2010 The Author(s). European Journal of Neurology © 2010 EFNS. |
Affiliation:
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Department of Neurology, University Clinic Essen, University of Duisburg-Essen, Essen, Germany Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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