| Peripheral nerve stimulation increases serotonin and dopamine metabolites in rat spinal cord. | |
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MedLine Citation:
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PMID: 7514945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracellular serotonin (5-HT), dopamine (DA), and their metabolites, 5-hydroxyindoleacetic acid (5-HIAA), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA), were assessed in the rat lumbar spinal cord (L3-4) by in vivo microdialysis with high performance liquid chromatography and electrochemical detection (HPLC-ECD). Under urethane-chloralose anesthesia, basal levels of 5-HT and DA in the dialysates were approximately 1.0-1.2 pg/22 microliters sample, 5-HIAA, DOPAC, and HVA were constant at 322.6 +/- 14.9, 8.6 +/- 0.7, and 10.4 +/- 0.4 pg/22 microliters sample (mean +/- SE), respectively. Local application of 100 mM KCl via the dialysis probe increased the 5-HT and DA. Peripheral nerve stimulation that selectively excited the large (A-beta) or small (A-delta) myelinated fibres increased the metabolites. Excitation of the A-beta fibers increased the levels of 5-HIAA to 138%, DOPAC to 155%, and HVA to 143% of the controls. Stimulation of the A-delta fibers increased 5-HIAA to 121%, DOPAC to 120%, and HVA to 124% of the controls. The results suggest that non-nociceptive peripheral nerve stimulation may activate the descending 5-HT and DA systems in the spinal cord. |
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Authors:
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D S Men; Y Matsui |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain research bulletin Volume: 33 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 1994 |
Date Detail:
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Created Date: 1994-06-30 Completed Date: 1994-06-30 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 625-32 Citation Subset: IM |
Affiliation:
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Department of Physiology, Showa University School of Dentistry, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism Animals Dopamine / metabolism* Electric Stimulation Female Homovanillic Acid / metabolism Hydroxyindoleacetic Acid / metabolism Microdialysis Peripheral Nerves / physiology* Potassium / pharmacology Rats Rats, Wistar Serotonin / metabolism* Spinal Cord / metabolism* |
| Chemical | |
Reg. No./Substance:
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102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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