Document Detail

Peripheral nerve stimulation increases serotonin and dopamine metabolites in rat spinal cord.
MedLine Citation:
PMID:  7514945     Owner:  NLM     Status:  MEDLINE    
Extracellular serotonin (5-HT), dopamine (DA), and their metabolites, 5-hydroxyindoleacetic acid (5-HIAA), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA), were assessed in the rat lumbar spinal cord (L3-4) by in vivo microdialysis with high performance liquid chromatography and electrochemical detection (HPLC-ECD). Under urethane-chloralose anesthesia, basal levels of 5-HT and DA in the dialysates were approximately 1.0-1.2 pg/22 microliters sample, 5-HIAA, DOPAC, and HVA were constant at 322.6 +/- 14.9, 8.6 +/- 0.7, and 10.4 +/- 0.4 pg/22 microliters sample (mean +/- SE), respectively. Local application of 100 mM KCl via the dialysis probe increased the 5-HT and DA. Peripheral nerve stimulation that selectively excited the large (A-beta) or small (A-delta) myelinated fibres increased the metabolites. Excitation of the A-beta fibers increased the levels of 5-HIAA to 138%, DOPAC to 155%, and HVA to 143% of the controls. Stimulation of the A-delta fibers increased 5-HIAA to 121%, DOPAC to 120%, and HVA to 124% of the controls. The results suggest that non-nociceptive peripheral nerve stimulation may activate the descending 5-HT and DA systems in the spinal cord.
D S Men; Y Matsui
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research bulletin     Volume:  33     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1994  
Date Detail:
Created Date:  1994-06-30     Completed Date:  1994-06-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  625-32     Citation Subset:  IM    
Department of Physiology, Showa University School of Dentistry, Tokyo, Japan.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Dopamine / metabolism*
Electric Stimulation
Homovanillic Acid / metabolism
Hydroxyindoleacetic Acid / metabolism
Peripheral Nerves / physiology*
Potassium / pharmacology
Rats, Wistar
Serotonin / metabolism*
Spinal Cord / metabolism*
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 7440-09-7/Potassium

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