| Peripheral nerve injury induces down-regulation of Foxo3a and p27kip1 in rat dorsal root ganglia. | |
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MedLine Citation:
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PMID: 18802749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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FOXO3a, as a forkhead transcription factor, can control cell cycle through transcriptionally down-regulating p27(kip1) level, which is a key regulator of the mammalian cell cycle and a good candidate to regulate multiple aspects of neurogenesis. To elucidate their expression and function in nervous system lesion and repair, we performed an acute sciatic nerve crush model and studied differential expressions of Foxo3a and p27(kip1) in lumbar dorsal root ganglia. Temporally, Foxo3a protein level was reduced 1 day after injury, and following Foxo3a down-regulation, p27(kip1) mRNA and protein levels were also decreased after injury. Spatially, decreased levels of Foxo3a and p27(kip1) were predominant in neurons and glial cells, which were regenerating axons and largely proliferated after injury, respectively. Together with previous reports, we hypothesized decreased levels of Foxo3a and p27(kip1) in lumbar dorsal root ganglia were implicated in axonal regeneration and the proliferation of glial cells after sciatic nerve injury. |
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Authors:
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Youhua Wang; Yonghua Liu; Ying Chen; Shuxian Shi; Jing Qin; Feng Xiao; Dan Zhou; Mudan Lu; Qiuyan Lu; Aiguo Shen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-19 |
Journal Detail:
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Title: Neurochemical research Volume: 34 ISSN: 1573-6903 ISO Abbreviation: Neurochem. Res. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-03-20 Completed Date: 2009-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: United States |
Other Details:
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Languages: eng Pagination: 891-8 Citation Subset: IM |
Affiliation:
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Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axons / physiology Cell Proliferation Cyclin-Dependent Kinase Inhibitor p27 / biosynthesis* Down-Regulation Forkhead Transcription Factors / biosynthesis* Ganglia, Spinal / metabolism*, pathology Lumbosacral Region Male Nerve Crush Nerve Regeneration Neuroglia / metabolism, pathology Neurons / metabolism, pathology Rats Rats, Sprague-Dawley Sciatic Nerve / injuries* |
| Chemical | |
Reg. No./Substance:
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0/Forkhead Transcription Factors; 0/Foxo3a protein, rat; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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