| Peripheral nerve conduction abnormalities in children exposed to alcohol in utero. | |
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MedLine Citation:
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PMID: 15001939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We performed a longitudinal study of nerve conduction velocity to determine the effect of prenatal alcohol exposure on the peripheral nervous system. Study design We studied 17 children exposed to >2 oz of absolute alcohol/day prenatally and 13 unexposed children, identified prospectively from a cohort of pregnant women screened during prenatal care. Nerve conduction assessment was done on the median, ulnar, peroneal and tibial nerves during the newborn period and between 12 and 14 months of age. RESULTS: At both assessments the alcohol-exposed subjects had significantly slower ulnar motor nerve velocity (P=.007), smaller proximal (P=.018) and distal amplitude (P=.051). They also showed reduced tibial nerve velocity (P=.06) and a decrease in distal amplitude. CONCLUSIONS: This study demonstrates that prenatal alcohol exposure is associated with abnormalities in nerve electrical properties, and that the pattern is different from that seen in adults. Electrophysiologic abnormalities in peripheral nerves should be added to the problems found in children of alcohol abusing mothers. |
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Authors:
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Mara de los Angeles Avaria; James L Mills; Karin Kleinsteuber; Sofia Aros; Mary R Conley; Christopher Cox; Mark Klebanoff; Fernando Cassorla |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pediatrics Volume: 144 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-05 Completed Date: 2004-04-15 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 338-43 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics and the Institute of Maternal and Child Research (IDIMI), Faculty of Medicine, University of Chile, Santiago, Chile. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Alcohol Drinking / adverse effects* Alcoholic Neuropathy / etiology* Efferent Pathways / physiopathology Female Humans Infant, Newborn Longitudinal Studies Neural Conduction* Neurons, Afferent / physiology Peripheral Nerves / injuries, physiopathology* Pregnancy Prenatal Exposure Delayed Effects* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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