| Peripheral mu-opioid receptors attenuate the augmented exercise pressor reflex in rats with chronic femoral artery occlusion. | |
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MedLine Citation:
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PMID: 20543079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently, opioid receptors have been shown to be expressed on group III and IV afferents, which comprise the sensory arm of the exercise pressor reflex. Although the stimulation of opioid receptors in the central nervous system has been shown to attenuate the exercise pressor reflex, the effect on the reflex of their stimulation in the periphery is unknown. We therefore tested the hypothesis that the activation of peripheral mu-opioid receptors attenuates the exercise pressor reflex. The pressor responses to static contraction were compared before and after the injection of the mu-opioid receptor agonist [d-Ala(2),N-MePhe(4),Gly-ol(5)]enkephalin (DAMGO; 1 microg) into the abdominal aorta of decerebrated rats in which one femoral artery had been occluded 72 h previously (n = 10) and in control rats whose femoral arteries were freely perfused (n = 8). DAMGO attenuated the peak pressor response to contraction in rats whose femoral arteries had been occluded (before: increase of 34 + or - 3 mmHg and after: increase of 22 + or - 2 mmHg, P = 0.008); the inhibitory effect of DAMGO was prevented by the injection of naloxone (100 microg) into the abdominal aorta (before: increase of 29 + or - 5 mmHg and after: increase of 29 + or - 5 mmHg, P = 0.646, n = 7). An intravenous injection of DAMGO (1 microg, n = 6) had no effect on the peak pressor response to contraction in both groups of rats. DAMGO had no effect on the peak pressor response to contraction in rats whose femoral arteries were freely perfused (before: Delta 23 + or - 4 mmHg, after: Delta 23 + or - 3 mmHg, n = 6) but appeared to have a small effect on topography of the response. DAMGO had no effect on the peak pressor response to tendon stretch in both groups of rats (both P > 0.05). We conclude that the stimulation of peripheral mu-opioid receptors attenuates the exercise pressor reflex in rats whose femoral arteries have been ligated for 72 h. |
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Authors:
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Hirotsugu Tsuchimochi; Jennifer L McCord; Marc P Kaufman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-06-11 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 299 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-30 Completed Date: 2010-08-30 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H557-65 Citation Subset: IM |
Affiliation:
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Penn State Heart and Vascular Institute, 500 University Dr., Mail Code H047, Hershey Medical Center, Hershey, PA 17033, USA. htsuchimochi@hmc.psu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterial Occlusive Diseases / metabolism*, physiopathology Baroreflex* / drug effects Chronic Disease Constriction, Pathologic Disease Models, Animal Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / administration & dosage Femoral Artery / innervation*, surgery Hindlimb Injections, Intra-Arterial Injections, Intravenous Ligation Male Muscle Contraction Muscle, Skeletal / blood supply*, innervation* Naloxone / administration & dosage Narcotic Antagonists / administration & dosage Neurons, Afferent / drug effects, metabolism Physical Exertion* Rats Rats, Sprague-Dawley Receptors, Opioid, mu / antagonists & inhibitors, metabolism* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01-AR-059397/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Narcotic Antagonists; 0/Receptors, Opioid, mu; 100929-53-1/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; 465-65-6/Naloxone |
| Comments/Corrections | |
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