Document Detail


Peripheral modulation of pheromone response by inhibitory host compound in a beetle.
MedLine Citation:
PMID:  20833926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We identified several compounds, by gas chromatographic-electroantennographic detection (GC-EAD), that were antennally active in the bark beetle Ips typographus and also abundant in beetle-attacked spruce trees. One of them, 1,8-cineole (Ci), strongly inhibited the attraction to pheromone in the field. Single-sensillum recordings (SSRs) previously showed olfactory receptor neurons (ORNs) on I. typographus antennae selectively responding to Ci. All Ci neurons were found within sensilla co-inhabited by a pheromone neuron responding to cis-verbenol (cV); however, in other sensilla, the cV neuron was paired with a neuron not responding to any test odorant. We hypothesized that the colocalization of ORNs had a functional and ecological relevance. We show by SSR that Ci inhibited spontaneous activity of the cV neuron only in sensilla in which the Ci neuron was also present. Using mixtures of cV and Ci, we further show that responses to low doses (1-10 ng) of cV were significantly reduced when the colocalized Ci neuron simultaneously responded to high doses (1-10 μg) of Ci. This indicated that the response of the Ci neuron, rather than ligand-receptor interactions in the cV neuron, caused the inhibition. Moreover, cV neurons paired with Ci neurons were more sensitive to cV alone than the ones paired with the non-responding ORN. Our observations question the traditional view that ORNs within a sensillum function as independent units. The colocalization of ORNs might sharpen adaptive responses to blends of semiochemicals with different ecological significance in the olfactory landscape.
Authors:
Martin N Andersson; Mattias C Larsson; Miroslav Blazenec; Rastislav Jakus; Qing-He Zhang; Fredrik Schlyter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of experimental biology     Volume:  213     ISSN:  1477-9145     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3332-9     Citation Subset:  IM    
Affiliation:
Chemical Ecology, Department of Plant Protection Biology, Swedish University of Agricultural Sciences, SE-230 53 Alnarp, Sweden. martin.andersson@ltj.slu.se
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MeSH Terms
Descriptor/Qualifier:
Animals
Beetles / drug effects,  pathogenicity*,  physiology*
Cyclohexanols / pharmacology
Gas Chromatography-Mass Spectrometry
Host-Parasite Interactions
Monoterpenes / pharmacology
Odors
Olfactory Receptor Neurons / drug effects,  physiology
Pheromones / pharmacology*
Picea / chemistry,  parasitology
Chemical
Reg. No./Substance:
0/Cyclohexanols; 0/Monoterpenes; 0/Pheromones; 470-82-6/cineole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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