| Peripheral mechanisms of intestinal dysmotility in the morphine tolerant and dependent rats. | |
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MedLine Citation:
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PMID: 16601316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes of intestinal motility and transit produced by tolerance to and dependence upon morphine have been partly attributed to peripheral mechanisms. We evaluated the effect of chronic peripheral morphine administration and peripheral mu-receptor blockade on vagal afferent activity (VAA) and c-Kit positive intramuscular cells of Cajal (ICCs). Ten rats were subjected to chronic subcutaneous morphine infusion for 72 h with subsequent VAA recording. Potential frequency was evaluated within recordings before and after mu receptor blockade by (D)-Phe -Cys -Tyr -(D)-Trp -Orn -Thr -Phe -Thr (CTOP) i.p. injections. Afterwards the rats were sacrificed and intramuscular c-Kit antigen expression was assessed by image analysis within removed fragments of duodenum and ascending colon. An equal group of rats served as a control for VAA and c-Kit expression. Analysis of VAA revealed similar frequencies of potentials in morphine tolerant / dependent rats before CTOP and in the controls. CTOP increased potential frequency in the morphine group which effect was visible mostly within the first 20 minutes (p=0.01). The morphine infused animals presented also higher c-Kit expression in both the duodenum (p<0.001) and the ascending colon (p<0.001) in comparison to the control group. Results of our study may indicate the involvement of both the intestinal wall and the long vago-vagal reflexes in tolerance to and dependence upon opioids. |
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Authors:
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T Banach; D Zurowski; K Gil; N W Weisbrodt; G Rosenfeld; P J Thor |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 57 ISSN: 0867-5910 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-04-07 Completed Date: 2006-05-22 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 73-82 Citation Subset: IM |
Affiliation:
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Dept. of Pathophysiology, Jagiellonian University Medical College, Cracow, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Colon / drug effects, metabolism Drug Tolerance / physiology Duodenum / drug effects, metabolism Gastrointestinal Motility / drug effects* Male Morphine / administration & dosage, toxicity* Morphine Dependence / physiopathology Neurons, Afferent / drug effects, physiology Proto-Oncogene Proteins c-kit / analysis, metabolism* Rats Rats, Wistar Receptors, Opioid, mu / antagonists & inhibitors, drug effects*, metabolism Somatostatin / analogs & derivatives, pharmacology Vagus Nerve / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Opioid, mu; 103429-31-8/phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide; 51110-01-1/Somatostatin; 57-27-2/Morphine; EC 2.7.10.1/Proto-Oncogene Proteins c-kit |
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