| Peripheral mechanisms in the control of appetite and related experimental therapies in obesity. | |
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MedLine Citation:
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PMID: 19409936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The function of the stomach and the gut hormonal responses to food ingestion constitute highly integrated homeostatic responses that maintain euglycemia and normal digestion. This intrinsic feedback involves vagal and hormonal mechanisms. Important signals such as GLP-1 and PYY that arise peripherally induce satiation and also delay gastric emptying or increase insulin secretion. Novel therapies are being developed to mimic or enhance these feedback mechanisms and to control appetite as a means to treat obesity. |
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Authors:
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Michael Camilleri |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2009-05-03 |
Journal Detail:
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Title: Regulatory peptides Volume: 156 ISSN: 1873-1686 ISO Abbreviation: Regul. Pept. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-06-29 Completed Date: 2009-09-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: Netherlands |
Other Details:
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Languages: eng Pagination: 24-7 Citation Subset: IM |
Affiliation:
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Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), College of Medicine, Mayo Clinic, Rochester, Minnesota, United States. camilleri.michael@mayo.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Obesity Agents / pharmacology, therapeutic use Appetite / drug effects, physiology* Gastrointestinal Motility / physiology Glucagon-Like Peptide 1 / metabolism, physiology Humans Incretins / metabolism, physiology Obesity / drug therapy, metabolism, surgery, therapy* Peptide YY / metabolism, physiology Satiation / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01-DK-067071/DK/NIDDK NIH HHS; R01-DK-54681/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Obesity Agents; 0/Incretins; 106388-42-5/Peptide YY; 89750-14-1/Glucagon-Like Peptide 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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