Document Detail


Peripheral mechanisms in the control of appetite and related experimental therapies in obesity.
MedLine Citation:
PMID:  19409936     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The function of the stomach and the gut hormonal responses to food ingestion constitute highly integrated homeostatic responses that maintain euglycemia and normal digestion. This intrinsic feedback involves vagal and hormonal mechanisms. Important signals such as GLP-1 and PYY that arise peripherally induce satiation and also delay gastric emptying or increase insulin secretion. Novel therapies are being developed to mimic or enhance these feedback mechanisms and to control appetite as a means to treat obesity.
Authors:
Michael Camilleri
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-05-03
Journal Detail:
Title:  Regulatory peptides     Volume:  156     ISSN:  1873-1686     ISO Abbreviation:  Regul. Pept.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-06-29     Completed Date:  2009-09-18     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  24-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Obesity Agents / pharmacology,  therapeutic use
Appetite / drug effects,  physiology*
Gastrointestinal Motility / physiology
Glucagon-Like Peptide 1 / metabolism,  physiology
Humans
Incretins / metabolism,  physiology
Obesity / drug therapy,  metabolism,  surgery,  therapy*
Peptide YY / metabolism,  physiology
Satiation / drug effects,  physiology
Grant Support
ID/Acronym/Agency:
R01 DK054681/DK/NIDDK NIH HHS; R01-DK-067071/DK/NIDDK NIH HHS; R01-DK-54681/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Obesity Agents; 0/Incretins; 106388-42-5/Peptide YY; 89750-14-1/Glucagon-Like Peptide 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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