Document Detail


Peripheral markers of thyroid status unaffected by endurance training in rats.
MedLine Citation:
PMID:  6785718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to more clearly define the relationship between endurance exercise training and thyroid activity we have measured T4 turnover in exercise-trained and sedentary rats under conditions of controlled food intake and body weight. Rats were run on rodent treadmills at gradually increasing speeds and durations until at the end of 12 weeks they were running 2 h per day at 31 m/min. Sedentary rats were either allowed to eat ad libitum or were food restricted so that they gained weight at the same rate as controls. Relative heart weight and plantaris citrate synthase activity were both significantly increased in trained animals compared to controls. The thyroxine secretion and degradation rates were not affected by the training. In addition, liver mitochondrial alpha-glycerophosphate dehydrogenase and citrate synthase were measured as indicators of the thyroid state at the tissue level. Neither of these enzymes were increased in the trained rats. We conclude that increased thyroid activity is not essential for inducing and maintaining the adaptations in muscle mitochondrial enzymes which occur in response to prolonged endurance exercise training.
Authors:
W W Winder; S J Garhart; B N Premachandra
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  389     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-07-09     Completed Date:  1981-07-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  195-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Citrate (si)-Synthase / metabolism
Diet
Glycerolphosphate Dehydrogenase / metabolism
Heart / physiology
Male
Mitochondria, Liver / enzymology
Organ Size / drug effects
Physical Education and Training*
Rats
Thyroid Gland / physiology*
Thyroxine / metabolism
Grant Support
ID/Acronym/Agency:
AM 00361/AM/NIADDK NIH HHS; AM 20384/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
7488-70-2/Thyroxine; EC 1.1.-/Glycerolphosphate Dehydrogenase; EC 2.3.3.1/Citrate (si)-Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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