Document Detail

Peripheral markers of brain damage and blood-brain barrier dysfunction.
MedLine Citation:
PMID:  14530574     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Occurrence of brain damage is frequently associated with abnormal blood-brain barrier (BBB) function. Two brain-specific proteins, S100beta and neuron-specific enolase (NSE) are released systemically in a variety of neurological diseases, but S100beta levels sometimes rise in the absence of neuronal damage, suggesting that S100beta is a marker of BBB rather than neuronal damage.
METHODS: We measured both proteins in the serum of patients undergoing iatrogenic BBB disruption with intrarterial mannitol, followed by chemotherapy.
RESULTS: Serum S100beta increased significantly after mannitol infusion (p<0.05) while NSE did not. Furthermore, in a model of intracerebral hemorrhage, S100beta increases in CSF did not lead to serum changes at a time when the BBB was intact. Modeling of S100beta release from the CNS suggested that low (<0.34 ng/ml) serum levels of S100beta are consistent with BBB opening without CNS damage, while larger increases imply synthesis and release from presumable damaged glia.
CONCLUSIONS: Thus, S100beta in serum is an early marker of BBB openings that may precede neuronal damage and may influence therapeutic strategies. Secondary, massive elevations in S100beta are indicators of prior brain damage and bear clinical significance as predictors of poor outcome or diagnostic means to differentiate extensive damage from minor, transient impairment.
Nicola Marchi; Peter Rasmussen; Miranda Kapural; Vince Fazio; Kelly Kight; Marc R Mayberg; Andrew Kanner; Barbara Ayumar; Ben Albensi; Marco Cavaglia; Damir Janigro
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Restorative neurology and neuroscience     Volume:  21     ISSN:  0922-6028     ISO Abbreviation:  Restor. Neurol. Neurosci.     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-07     Completed Date:  2004-01-07     Revised Date:  2014-06-24    
Medline Journal Info:
Nlm Unique ID:  9005499     Medline TA:  Restor Neurol Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  109-21     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood*
Blood-Brain Barrier / metabolism*,  pathology
Brain Diseases / blood,  pathology
Hypoxia, Brain / blood*,  pathology
Nerve Growth Factors / blood
Phosphopyruvate Hydratase / blood
S100 Calcium Binding Protein beta Subunit
S100 Proteins / blood
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Nerve Growth Factors; 0/S100 Calcium Binding Protein beta Subunit; 0/S100 Proteins; EC Hydratase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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