Document Detail


Peripheral markers of brain damage and blood-brain barrier dysfunction.
MedLine Citation:
PMID:  14530574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Occurrence of brain damage is frequently associated with abnormal blood-brain barrier (BBB) function. Two brain-specific proteins, S100beta and neuron-specific enolase (NSE) are released systemically in a variety of neurological diseases, but S100beta levels sometimes rise in the absence of neuronal damage, suggesting that S100beta is a marker of BBB rather than neuronal damage.
METHODS: We measured both proteins in the serum of patients undergoing iatrogenic BBB disruption with intrarterial mannitol, followed by chemotherapy.
RESULTS: Serum S100beta increased significantly after mannitol infusion (p<0.05) while NSE did not. Furthermore, in a model of intracerebral hemorrhage, S100beta increases in CSF did not lead to serum changes at a time when the BBB was intact. Modeling of S100beta release from the CNS suggested that low (<0.34 ng/ml) serum levels of S100beta are consistent with BBB opening without CNS damage, while larger increases imply synthesis and release from presumable damaged glia.
CONCLUSIONS: Thus, S100beta in serum is an early marker of BBB openings that may precede neuronal damage and may influence therapeutic strategies. Secondary, massive elevations in S100beta are indicators of prior brain damage and bear clinical significance as predictors of poor outcome or diagnostic means to differentiate extensive damage from minor, transient impairment.
Authors:
Nicola Marchi; Peter Rasmussen; Miranda Kapural; Vince Fazio; Kelly Kight; Marc R Mayberg; Andrew Kanner; Barbara Ayumar; Ben Albensi; Marco Cavaglia; Damir Janigro
Related Documents :
9539604 - The effect of prior dural puncture on cerebrospinal fluid sufentanil concentrations in ...
16464944 - Increased cortisol in the cerebrospinal fluid of women with functional hypothalamic ame...
422254 - Lack of penetration of cephacetril into the cerebro-spinal fluid of patients without me...
1519424 - Cerebrospinal fluid and blood concentrations of luteinizing hormone, follicle stimulati...
7903264 - Differential effects of somatostatin-14 and somatostatin-25 on carbohydrate and lipid m...
10801994 - Effect of pravastatin on plasma removal of a chylomicron-like emulsion in men with coro...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Restorative neurology and neuroscience     Volume:  21     ISSN:  0922-6028     ISO Abbreviation:  Restor. Neurol. Neurosci.     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-07     Completed Date:  2004-01-07     Revised Date:  2014-06-24    
Medline Journal Info:
Nlm Unique ID:  9005499     Medline TA:  Restor Neurol Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  109-21     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / blood*
Blood-Brain Barrier / metabolism*,  pathology
Brain Diseases / blood,  pathology
Humans
Hypoxia, Brain / blood*,  pathology
Nerve Growth Factors / blood
Phosphopyruvate Hydratase / blood
S100 Calcium Binding Protein beta Subunit
S100 Proteins / blood
Grant Support
ID/Acronym/Agency:
HL51614/HL/NHLBI NIH HHS; NS38195/NS/NINDS NIH HHS; NS43284/NS/NINDS NIH HHS; R01 NS038195/NS/NINDS NIH HHS; R01 NS049514/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Nerve Growth Factors; 0/S100 Calcium Binding Protein beta Subunit; 0/S100 Proteins; EC 4.2.1.11/Phosphopyruvate Hydratase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Janus face of glial-derived S100B: beneficial and detrimental functions in the brain.
Next Document:  Molecular markers of brain damage--clinical and ethical implications with particular focus on cardia...