| Peripheral leptin levels in narcoleptic patients. | |
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MedLine Citation:
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PMID: 17705690 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Narcolepsy is a severe sleep disorder that in most patients is characterized by the deficiency of central orexin. Clinically, narcolepsy is associated with obesity. Currently, there is a literature controversy about the potential alteration of leptin levels in narcoleptic patients. Theoretically, diminished leptin levels could partially contribute to the observed overweight of patients. Two studies have reported decreased leptin levels, whereas a larger, recent study failed to detect differences between patients and controls. METHODS: To help settle the controversy, we have measured peripheral leptin levels in 42 narcoleptic patients and in 31 body mass index-matched controls. RESULTS: No significant differences in leptin levels between the groups were observed. Mean leptin levels were 16.0 +/- 14.9 ng/mL in the narcoleptic men and 30.4 +/- 17.8 ng/mL in the narcoleptic women. The corresponding values for the controls were 21.2 +/- 17.0 ng/mL (P = 0.49, men) and 33.9 +/- 16.9 ng/mL (P = 0.31, women). In addition, no correlation was found between leptin levels and clinical symptomatology in the narcoleptic patients. CONCLUSIONS: Taken together, the data argue against a major deterioration of leptin secretion in narcoleptic patients. |
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Authors:
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Norbert Dahmen; Alice Engel; Jana Helfrich; Nina Manderscheid; Mirjam Löbig; Thomas Forst; Andreas Pfützner; Peter Tonn |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes technology & therapeutics Volume: 9 ISSN: 1520-9156 ISO Abbreviation: Diabetes Technol. Ther. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-20 Completed Date: 2007-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100889084 Medline TA: Diabetes Technol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 348-53 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Mainz, Mainz, Germany. ndahmen@mail.psychiatrie.klinik.unimainz.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Body Mass Index Female Humans Leptin / blood*, secretion Male Middle Aged Narcolepsy / blood* Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Leptin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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