| Peripheral kappa-opioid agonist, ICI 204448, evokes hypothermia in cold-exposed rats. | |
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MedLine Citation:
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PMID: 15687734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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ICI 204448, a selective kappa-opioid agonist with limited CNS access, can be used to discriminate central and peripheral opioid actions on physiological systems such as pain and thermoregulation. Therefore, we investigated the effect of ICI 204448 (2.5, 5, and 10 mg/kg, s.c.) on male Sprague-Dawley rats exposed to ambient temperatures of 5, 20, or 32 degrees C. ICI 204448 did not alter the body temperature of rats maintained at 20 or 32 degrees C. However, 5 and 10 mg/kg of ICI 204448 evoked significant hypothermia in rats exposed to 5 degrees C. The i.c.v. administration of nor-BNI, a kappa-opioid antagonist, did not affect the hypothermia produced by the systemic injection of ICI 204448. Thus, an involvement of brain kappa-opioid receptors in ICI 204448-evoked hypothermia is unlikely. The present data demonstrate for the first time that ICI 204448 produces hypothermia in cold-exposed rats and suggest that the role of peripheral kappa-opioid receptors in thermoregulation becomes more significant at cold ambient temperatures. |
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Authors:
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Scott M Rawls; Zhe Ding; Alex M Gray; Alan Cowan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. Date: 2005-01-12 |
Journal Detail:
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Title: Pharmacology Volume: 74 ISSN: 0031-7012 ISO Abbreviation: Pharmacology Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-31 Completed Date: 2005-08-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0152016 Medline TA: Pharmacology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 79-83 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2005 S. Karger AG, Basel. |
Affiliation:
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Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA. scott.rawls@temple.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / drug effects* Cold Temperature* Hypothermia / chemically induced*, metabolism Injections, Subcutaneous Male Pyrrolidines / pharmacology* Rats Rats, Sprague-Dawley Receptors, Opioid, kappa / agonists* |
| Grant Support | |
ID/Acronym/Agency:
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DA 13429/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Pyrrolidines; 0/Receptors, Opioid, kappa; 121264-04-8/ICI 204448 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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