| Peripheral ghrelin stimulates feeding behavior and positive energy balance in a sciurid hibernator. | |
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MedLine Citation:
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PMID: 21310157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hibernators exhibit a robust circannual cycle of body mass gain and loss primarily mediated by food intake, but the pathways controlling food intake in these animals have not been fully elucidated. Ghrelin is an orexigenic hormone that increases feeding in all mammals studied so far, but has not until recently been studied in hibernators. In other mammals, ghrelin stimulates feeding through phosphorylation and activation of AMP-activated protein kinase (AMPK). Activation of AMPK phosphorylates and deactivates acetyl Co-A carboxylase (ACC), a committed step in fatty acid synthesis. In order to determine the effects of exogenous ghrelin on food intake and metabolic factors (i.e. non-esterified fatty acids (NEFAs), and hypothalamic AMPK and ACC) in hibernators, ghrelin was peripherally injected into ground squirrels in all four seasons. Changes in food intake and body mass were recorded over a 2-6 hour period post injections, and squirrels were euthanized. Brains and blood were removed, and Western blots were performed to determine changes in phosphorylation of hypothalamic AMPK and ACC. A colorimetric assay was used to determine changes in concentration of serum NEFAs. We found that food intake, body mass, and locomotor activity significantly increased with ghrelin injections versus saline-injected controls, even in animals injected during their aphagic winter season. Injected ghrelin was correlated with increased phosphorylation of AMPK, but didn't have an effect on ACC in winter. Ghrelin-injected animals also had increased levels of serum NEFAs compared with saline controls. This study is the first to show an effect of injected ghrelin on a hibernator. |
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Authors:
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Jessica E Healy; Jenna L Bateman; Cara E Ostrom; Gregory L Florant |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-02-17 |
Journal Detail:
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Title: Hormones and behavior Volume: 59 ISSN: 1095-6867 ISO Abbreviation: Horm Behav Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-22 Completed Date: 2011-08-15 Revised Date: 2013-05-26 |
Medline Journal Info:
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Nlm Unique ID: 0217764 Medline TA: Horm Behav Country: United States |
Other Details:
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Languages: eng Pagination: 512-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Biology, Colorado State University, Fort Collins, CO 85023, USA. jehealy@email.arizona.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetyl-CoA Carboxylase
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metabolism Adenylate Kinase / metabolism Analysis of Variance Animals Blotting, Western Body Weight / drug effects, physiology Eating / drug effects, physiology Energy Metabolism / drug effects*, physiology Fatty Acids, Nonesterified / metabolism Feeding Behavior / drug effects*, physiology Ghrelin / pharmacology* Hypothalamus / drug effects*, metabolism Motor Activity / drug effects*, physiology Phosphorylation / drug effects Random Allocation Sciuridae |
| Grant Support | |
ID/Acronym/Agency:
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DK 067017-3/DK/NIDDK NIH HHS; R25 DK067017-03/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Ghrelin; EC 2.7.4.3/Adenylate Kinase; EC 6.4.1.2/Acetyl-CoA Carboxylase |
| Comments/Corrections | |
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