| Peripheral fat loss and decline in adipogenesis in older humans. | |
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MedLine Citation:
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PMID: 22999012 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Aging is associated with a redistribution of body fat including a relative loss of subcutaneous peripheral fat. These changes in body fat can have important clinical consequences since they are linked to increased risk of metabolic complications. The causes and mechanisms of loss of peripheral fat associated with aging are not clear. The aim of this study was to assess whether defects in adipogenesis contribute to fat loss in aging humans, as suggested from animal studies, and to evaluate the role of inflammation on pathogenesis of fat loss. MATERIALS/METHODS: Preadipocytes isolated from subcutaneous peripheral fat of healthy young and elderly subjects were compared in their ability to replicate and differentiate. RESULTS: The results show that both the rate of replication and differentiation of preadipocytes are reduced in older subjects. The reduction in adipogenesis is accompanied by a higher plasma level of the inflammatory marker, soluble tumor necrosis factor receptor 2, and greater release of tumor necrosis factor α from fat tissue. CONCLUSIONS: Thus, the gradual relative loss of peripheral fat in aging humans may in part result from a defect in adipogenesis, which may be linked to inflammation and increased release of proinflammatory cytokines from fat tissue. |
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Authors:
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Giuseppe Caso; Margaret A McNurlan; Izolda Mileva; Alla Zemlyak; Dennis C Mynarcik; Marie C Gelato |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-18 |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: - ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Surgery, Stony Brook University Medical Center, Stony Brook, NY 11794-8191, USA. Electronic address: Giuseppe.Caso@stonybrook.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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