Document Detail


Peripheral fat loss and decline in adipogenesis in older humans.
MedLine Citation:
PMID:  22999012     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Aging is associated with a redistribution of body fat including a relative loss of subcutaneous peripheral fat. These changes in body fat can have important clinical consequences since they are linked to increased risk of metabolic complications. The causes and mechanisms of loss of peripheral fat associated with aging are not clear. The aim of this study was to assess whether defects in adipogenesis contribute to fat loss in aging humans, as suggested from animal studies, and to evaluate the role of inflammation on pathogenesis of fat loss.
MATERIALS/METHODS: Preadipocytes isolated from subcutaneous peripheral fat of healthy young and elderly subjects were compared in their ability to replicate and differentiate.
RESULTS: The results show that both the rate of replication and differentiation of preadipocytes are reduced in older subjects. The reduction in adipogenesis is accompanied by a higher plasma level of the inflammatory marker, soluble tumor necrosis factor receptor 2, and greater release of tumor necrosis factor α from fat tissue.
CONCLUSIONS: Thus, the gradual relative loss of peripheral fat in aging humans may in part result from a defect in adipogenesis, which may be linked to inflammation and increased release of proinflammatory cytokines from fat tissue.
Authors:
Giuseppe Caso; Margaret A McNurlan; Izolda Mileva; Alla Zemlyak; Dennis C Mynarcik; Marie C Gelato
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-09-19
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  62     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-19     Completed Date:  2013-07-01     Revised Date:  2014-03-09    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337-40     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adipocytes / metabolism*
Adipogenesis / physiology*
Adolescent
Adult
Age Factors
Aged
Cell Differentiation / physiology
Humans
Inflammation / metabolism
Receptors, Tumor Necrosis Factor, Type II / blood,  metabolism
Subcutaneous Fat / metabolism*
Tumor Necrosis Factor-alpha / metabolism
Young Adult
Grant Support
ID/Acronym/Agency:
5-MO1-RR-10710/RR/NCRR NIH HHS; AG017446/AG/NIA NIH HHS; DK049316/DK/NIDDK NIH HHS; M01 RR010710/RR/NCRR NIH HHS; R01 AG017446/AG/NIA NIH HHS; R01 DK049316/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Tumor Necrosis Factor, Type II; 0/Tumor Necrosis Factor-alpha
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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