Document Detail

Peripheral factors in the pathophysiology of irritable bowel syndrome.
MedLine Citation:
PMID:  19665956     Owner:  NLM     Status:  MEDLINE    
The pathophysiology of IBS is complex and still incompletely known. Both central and peripheral factors are thought to contribute to the symptoms of IBS, including psychosocial factors, abnormal GI motility and secretion, and visceral hypersensitivity. In this review the involvement of peripheral factors in the pathophysiology in IBS is reviewed. Altered GI motility is commonly found in this patient group, even though a specific motor pattern has been hard to find. Colonic transit has been found to be of relevance for the bowel habit of the patient. Abnormal gas handling within the gut is also commonly seen, and seems to be one, but not the only factor responsive for bloating. There is also limited evidence supporting the presence of abnormal GI secretion in IBS, but its relevance for symptoms remains unclear. Visceral hypersensitivity is currently considered to be one of the most important pathophysiological factors in IBS. It can be modulated by several external and internal factors and recent studies support an association between colorectal sensitivity and the symptoms reported by the patients, especially pain.
J Gunnarsson; M Simr??n
Related Documents :
7663906 - Bile acid dysfunction after clam enterocystoplasty.
21401396 - Effectiveness of single flexible ureteroscopy for multiple renal calculi.
24269416 - Hyperhomocysteinemia in chronic alcoholism: a case with retinal manifestations.
12894366 - Surgical intervention for acute intestinal ischemia: experience in a community teaching...
21574156 - Chromogranin a measurement in metastatic well-differentiated gastroenteropancreatic neu...
2084236 - Adverse experience with methotrexate during 176 weeks of a longterm prospective trial i...
Publication Detail:
Type:  Journal Article; Review     Date:  2009-08-08
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  41     ISSN:  1878-3562     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-09     Completed Date:  2010-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  788-93     Citation Subset:  IM    
Department of Internal Medicine, Sahlgrenska University Hospital, G??teborg, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Gastrointestinal Motility
Irritable Bowel Syndrome / physiopathology*,  psychology*
Pain Threshold / psychology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Why are Cochrane hepato-biliary reviews undervalued by physicians as an aid for clinical decision-ma...
Next Document:  Limb lengthening and deformity correction in children using hexapodal external fixation: preliminary...