Document Detail


Peripheral factors in the pathophysiology of irritable bowel syndrome.
MedLine Citation:
PMID:  19665956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pathophysiology of IBS is complex and still incompletely known. Both central and peripheral factors are thought to contribute to the symptoms of IBS, including psychosocial factors, abnormal GI motility and secretion, and visceral hypersensitivity. In this review the involvement of peripheral factors in the pathophysiology in IBS is reviewed. Altered GI motility is commonly found in this patient group, even though a specific motor pattern has been hard to find. Colonic transit has been found to be of relevance for the bowel habit of the patient. Abnormal gas handling within the gut is also commonly seen, and seems to be one, but not the only factor responsive for bloating. There is also limited evidence supporting the presence of abnormal GI secretion in IBS, but its relevance for symptoms remains unclear. Visceral hypersensitivity is currently considered to be one of the most important pathophysiological factors in IBS. It can be modulated by several external and internal factors and recent studies support an association between colorectal sensitivity and the symptoms reported by the patients, especially pain.
Authors:
J Gunnarsson; M Simr??n
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-08-08
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  41     ISSN:  1878-3562     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-09     Completed Date:  2010-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  788-93     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Sahlgrenska University Hospital, G??teborg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Gastrointestinal Motility
Humans
Irritable Bowel Syndrome / physiopathology*,  psychology*
Pain Threshold / psychology*

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