| Peripheral dopamine metabolism in polycystic ovary syndrome. | |
| | |
MedLine Citation:
|
PMID: 3601275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It has been proposed that a relative dopamine deficiency or an increased sensitivity of the gonadotrope to dopamine may explain the elevated luteinizing hormone (LH) levels characteristic of polycystic ovary syndrome. To study one aspect of this issue, that of peripheral dopamine metabolism in polycystic ovary syndrome, we measured the conversion of dopamine to norepinephrine after intravenous dopamine infusions in women with polycystic ovary syndrome and in matched controls. In addition, we measured urinary metabolites of dopamine and norepinephrine, which reflect in part central catecholamine turnover, after daily ingestion of L-dopa with carbidopa, which increases brain dopamine levels. After dopamine infusion in women with polycystic ovary syndrome and in matched controls, steady state levels of plasma dopamine, norepinephrine, and the ratio of dopamine/norepinephrine were similar in the two groups. Similarly, urinary metabolites of dopamine, norepinephrine, and their ratios were not different in patients and controls after L-dopa with carbidopa. We suggest that no major alterations in dopamine metabolism exist in these patients with polycystic ovary syndrome. |
| | |
Authors:
|
R B Barnes; R Artal; R A Lobo |
Related Documents
:
|
9237505 - Polycystic kidney disease, biliary dysgenesis in a patient with larsen's syndrome. 15941725 - Androgen excess fetal programming of female reproduction: a developmental aetiology for... 11984435 - Diet and polycystic ovary syndrome. 19673875 - Targeted treatment of pyoderma gangrenosum in papa (pyogenic arthritis, pyoderma gangre... 3712395 - An additional case of smith-lemli-opitz syndrome in a 46,xy infant with female external... 8002775 - A self-controllable mask with helmet to prevent self finger-mutilation in the lesch-nyh... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Obstetrics and gynecology Volume: 70 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1987 Aug |
Date Detail:
|
Created Date: 1987-08-19 Completed Date: 1987-08-19 Revised Date: 2009-10-26 |
Medline Journal Info:
|
Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 153-6 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Carbidopa / therapeutic use Dopamine / blood, metabolism* Female Homovanillic Acid / urine Humans Levodopa / therapeutic use Methoxyhydroxyphenylglycol / urine Norepinephrine / blood Polycystic Ovary Syndrome / blood, drug therapy, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
HD 17519-01/HD/NICHD NIH HHS; RR-43/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Levodopa; 306-08-1/Homovanillic Acid; 38821-49-7/Carbidopa; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Quantitation of proteinuria in pregnancy by the use of single voided urine samples.
Next Document: Alteration of follicle regulatory protein levels in human reproductive disorders: anovulation.