Document Detail


Peripheral decrease and pulmonary homing of CD4+CD45RO+ helper memory T cells in cystic fibrosis.
MedLine Citation:
PMID:  11860174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interstitial lung disease, although of prognostic impact for patients with cystic fibrosis (CF), remains difficult to assess without histopathologic investigations. As changes of peripheral blood lymphocyte subsets (LS) may accompany severe systemic lymphocyte immune responses, we compared peripheral LS of 44 patients with CF, 23 non-CF patients with recurrent pulmonary infections and 83 healthy controls (flow cytometry; CD3, CD19, CD16, CD56, CD4, CD8, CD11b, CD45RA, CD45RO, HLA-DR and CD25 antigens). Additional immunohistochemistry was performed on lung tissue of four CF patients aged 0.5, 12, 17 and 20 years, respectively. Patients with CF showed low absolute counts of CD4+CD45RO+ memory helperT cells, CD16+CD56+ NK cells, CD8+ and interleukin-2 receptor-positive T cells in peripheral blood (P < 0.001). Similar changes were registered in the non-CF patients with pulmonary infections, indicating that those were not specific for CF. Immunohistochemistry showed activation of bronchus-associated lymphoid tissue with interstitial accumulation of CD4+CD45 RO+ T cells in the three older patients. Patients with CF show marked changes of peripheral blood LS which are presumably not CF-specific and may mirror homing to lung tissue in the course of interstitial lung disease. Further research should evaluate its usefulness in monitoring progression of lung disease in CF.
Authors:
M Häusler; K Schweizer; S Biesterfel; T Opladen; G Heimann
Related Documents :
7353424 - Prolonged survival in an adult with cystic fibrosis.
18558214 - Congenital bilateral absence of the vas deferens.
7086584 - Improved respiratory prognosis in patients with cystic fibrosis with normal fat absorpt...
20169264 - Anesthesia for partial bilateral salpingectomy in a patient with idiopathic hypertrophi...
22560944 - Risk factor modification in diabetic patients following angiographic identification of ...
1302804 - Fungaemia due to candida pelliculosa in a case of acute pancreatitis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiratory medicine     Volume:  96     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-25     Completed Date:  2002-03-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  87-94     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University Hospital, RWTH Aachen, Germany. Haeusler@RWTH-Aachen.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antigens, CD45
CD4 Lymphocyte Count
Case-Control Studies
Child
Child, Preschool
Cystic Fibrosis / immunology*
Female
Flow Cytometry
Humans
Immunity, Cellular
Immunologic Memory
Immunophenotyping
Infant
Infant, Newborn
Lung / immunology*
Lung Diseases / immunology
Lymphoid Tissue
Male
Prospective Studies
Statistics, Nonparametric
T-Lymphocytes, Helper-Inducer / immunology*
Chemical
Reg. No./Substance:
EC 3.1.3.48/Antigens, CD45

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung.
Next Document:  The NADH: ubiquinone oxidoreductase (complex I) of the mammalian respiratory chain and the cAMP casc...