Document Detail

Peripheral decrease and pulmonary homing of CD4+CD45RO+ helper memory T cells in cystic fibrosis.
MedLine Citation:
PMID:  11860174     Owner:  NLM     Status:  MEDLINE    
Interstitial lung disease, although of prognostic impact for patients with cystic fibrosis (CF), remains difficult to assess without histopathologic investigations. As changes of peripheral blood lymphocyte subsets (LS) may accompany severe systemic lymphocyte immune responses, we compared peripheral LS of 44 patients with CF, 23 non-CF patients with recurrent pulmonary infections and 83 healthy controls (flow cytometry; CD3, CD19, CD16, CD56, CD4, CD8, CD11b, CD45RA, CD45RO, HLA-DR and CD25 antigens). Additional immunohistochemistry was performed on lung tissue of four CF patients aged 0.5, 12, 17 and 20 years, respectively. Patients with CF showed low absolute counts of CD4+CD45RO+ memory helperT cells, CD16+CD56+ NK cells, CD8+ and interleukin-2 receptor-positive T cells in peripheral blood (P < 0.001). Similar changes were registered in the non-CF patients with pulmonary infections, indicating that those were not specific for CF. Immunohistochemistry showed activation of bronchus-associated lymphoid tissue with interstitial accumulation of CD4+CD45 RO+ T cells in the three older patients. Patients with CF show marked changes of peripheral blood LS which are presumably not CF-specific and may mirror homing to lung tissue in the course of interstitial lung disease. Further research should evaluate its usefulness in monitoring progression of lung disease in CF.
M Häusler; K Schweizer; S Biesterfel; T Opladen; G Heimann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiratory medicine     Volume:  96     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-25     Completed Date:  2002-03-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  87-94     Citation Subset:  IM    
Department of Pediatrics, University Hospital, RWTH Aachen, Germany.
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MeSH Terms
Antigens, CD45
CD4 Lymphocyte Count
Case-Control Studies
Child, Preschool
Cystic Fibrosis / immunology*
Flow Cytometry
Immunity, Cellular
Immunologic Memory
Infant, Newborn
Lung / immunology*
Lung Diseases / immunology
Lymphoid Tissue
Prospective Studies
Statistics, Nonparametric
T-Lymphocytes, Helper-Inducer / immunology*
Reg. No./Substance:
EC, CD45

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