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Peripheral corticotropin-releasing factor (CRF) induces stimulation of gastric contractions in freely moving conscious rats: role of CRF receptor types 1 and 2.
MedLine Citation:
PMID:  23205497     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background  Peripheral corticotrophin-releasing factor (CRF) plays an important role in stress-induced alterations of gastrointestinal motility. CRF injected peripherally inhibits gastric emptying, but its effect on gastric contractions has not been clarified in freely moving conscious rats. Methods  Intraluminal gastric pressure waves were measured in freely moving conscious non-fasted rats using the perfused manometric method. We assessed the area under the manometric trace as the motor index (MI), and compared this result with those obtained 1 h before and after drug administration. Key Results  Subcutaneous injection (sc) of CRF (15 μg kg(-1) ) increased the MI significantly. Pretreatment with intravenous astressin (100 μg kg(-1) ), a non-selective CRF antagonist, blocked the sc CRF (15 μg kg(-1) )-induced response, but astressin(2) -B (200 μg kg(-1) , sc), a selective CRF receptor type 2 (CRF(2) ) antagonist, enhanced the CRF-induced increase in MI significantly. Meanwhile urocortin 2 (15 μg kg(-1) , sc), a selective CRF(2) agonist, did not alter the basal MI, but it inhibited the sc CRF (15 μg kg(-1) )-induced stimulation of gastric contractions. The intraperitoneal injection of cortagine (30 μg kg(-1) ), a selective CRF receptor type 1 (CRF(1) ) agonist, mimicked the response induced by sc CRF. Conclusions & Inferences  Peripheral CRF stimulates gastric contractions through CRF(1) . CRF(2) activation inhibits the response induced by CRF, suggesting that CRF(2) may have a modulatory action to CRF(1) signaling in gastric motor activity.
Authors:
T Nozu; Y Tsuchiya; S Kumei; K Takakusaki; T Okumura
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  -     ISSN:  1365-2982     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Department of Regional Medicine and Education, Asahikawa Medical University, Asahikawa, Japan Department of General Medicine, Asahikawa Medical University, Asahikawa, Japan Research Center for Brain Function and Medical Engineering, Asahikawa Medical University, Asahikawa, Japan.
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