| Peripheral concentrations of gonadotropins and progestins during pregnancy in rabbits after active immunization against testosterone. | |
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MedLine Citation:
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PMID: 6790308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of active immunization of female rabbits against testosterone on various endocrine parameters during pregnancy were examined. Peripheral blood samples were obtained from immunized rabbits at timed intervals after mating up to the 29th day of pregnancy, when the rabbits were killed and various tissues were analyzed. Progesterone concentrations were higher in testosterone-immunized rabbits (TIR) than in controls during pregnancy. Luteinizing hormone (LH) and follicle-stimulating hormone concentrations were not significantly different in controls and TIR during pregnancy. Both progestins and gonadotropins showed the expected coitus-induced increases, but LH levels were higher in TIR. The binding of testosterone in fetal plasma and amniotic fluid was higher in TIR than in controls. Weights of fetuses and litter size were not significantly different in TIR and controls. These data suggest that testosterone may play a role during pregnancy in the rabbit. |
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Authors:
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E V Younglai; R W Armstrong |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Fertility and sterility Volume: 36 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1981 Aug |
Date Detail:
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Created Date: 1981-10-29 Completed Date: 1981-10-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 232-7 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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immunology Animals Binding Sites, Antibody Copulation Female Fetus / immunology Follicle Stimulating Hormone / blood Gonadotropins / blood* Immunity, Active Luteinizing Hormone / blood Male Pregnancy Progestins / blood* Rabbits Testosterone / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Binding Sites, Antibody; 0/Gonadotropins; 0/Progestins; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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