Document Detail


Peripheral chemosensing system for tastants and nutrients.
MedLine Citation:
PMID:  22157399     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: The purpose of this review is to discuss the presence and possible roles of peripheral taste/nutrient sensors, particularly taste receptors. RECENT FINDINGS: Recent studies have demonstrated that taste signaling molecules are distributed not only in the gustatory epithelium, but also in other tissues, including the gastrointestinal tract, airways, testes and brain. Taste signaling mechanisms in the gastrointestinal tract were reported to participate in detecting sweet, umami and bitter compounds. Several research groups have suggested that tastant/nutrient detection by other systems contributes to the behavioral responses to food intake. SUMMARY: Taste-like cells expressing taste signaling components are distributed in multiple tissues. Investigation of their potential roles in chemosensing has just begun. Researchers have identified at least two chemosensory pathways in the gastrointestinal tract for detecting tastants/nutrients. One is the taste receptor signaling pathway and the other is the currently unknown nutrient-sensing pathway that elicits postingestive effects. The former system utilizes a mechanism similar to taste sensing in the oral cavity. By understanding how tastants/nutrients are sensed and regulated through both systems, we may be able to more effectively control food intake in the future.
Authors:
Ken Iwatsuki; Kunio Torii
Related Documents :
2504639 - Intestinal permeability to 51cr-labelled ethylenediaminetetraacetate in food-intolerant...
20172659 - Drug-induced gingival hyperplasia and scaffolds: they may be valuable for horizontal fo...
8740109 - Prevalence of hepatitis a antibodies in food handlers in italy.
22002569 - Factors affecting food security and contribution of modern technologies in food sustain...
10087989 - Splenic "regeneration" after partial splenectomy for gaucher disease: histological feat...
7684529 - Esophagorespiratory fistula associated with esophageal cancer: treatment with a giantur...
1594679 - Analysis of the relationships between self-stimulation sniffing and brain-stimulation s...
20534729 - Egr1 is a target for cooperative interactions between cholecystokinin and leptin, and i...
11842999 - The history and future of food fortification in the united states: a public health pers...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-9
Journal Detail:
Title:  Current opinion in endocrinology, diabetes, and obesity     Volume:  -     ISSN:  1752-2978     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101308636     Medline TA:  Curr Opin Endocrinol Diabetes Obes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute for Innovation, Ajinomoto Co. Inc., Kawasaki-ku, Kawasaki, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Biology and pharmacology of bombesin receptor subtype-3.
Next Document:  Diagnosis of growth hormone deficiency in childhood.