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Peripheral chemosensing system for tastants and nutrients.
MedLine Citation:
PMID:  22157399     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: The purpose of this review is to discuss the presence and possible roles of peripheral taste/nutrient sensors, particularly taste receptors. RECENT FINDINGS: Recent studies have demonstrated that taste signaling molecules are distributed not only in the gustatory epithelium, but also in other tissues, including the gastrointestinal tract, airways, testes and brain. Taste signaling mechanisms in the gastrointestinal tract were reported to participate in detecting sweet, umami and bitter compounds. Several research groups have suggested that tastant/nutrient detection by other systems contributes to the behavioral responses to food intake. SUMMARY: Taste-like cells expressing taste signaling components are distributed in multiple tissues. Investigation of their potential roles in chemosensing has just begun. Researchers have identified at least two chemosensory pathways in the gastrointestinal tract for detecting tastants/nutrients. One is the taste receptor signaling pathway and the other is the currently unknown nutrient-sensing pathway that elicits postingestive effects. The former system utilizes a mechanism similar to taste sensing in the oral cavity. By understanding how tastants/nutrients are sensed and regulated through both systems, we may be able to more effectively control food intake in the future.
Authors:
Ken Iwatsuki; Kunio Torii
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-9
Journal Detail:
Title:  Current opinion in endocrinology, diabetes, and obesity     Volume:  -     ISSN:  1752-2978     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101308636     Medline TA:  Curr Opin Endocrinol Diabetes Obes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute for Innovation, Ajinomoto Co. Inc., Kawasaki-ku, Kawasaki, Japan.
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