Document Detail

Peripheral chemoreceptor function after carbonic anhydrase inhibition during moderate-intensity exercise.
MedLine Citation:
PMID:  10233116     Owner:  NLM     Status:  MEDLINE    
The effect of carbonic anhydrase inhibition with acetazolamide (Acz, 10 mg/kg) on the ventilatory response to an abrupt switch into hyperoxia (end-tidal PO2 = 450 Torr) and hypoxia (end-tidal PO2 = 50 Torr) was examined in five male subjects [30 +/- 3 (SE) yr]. Subjects exercised at a work rate chosen to elicit an O2 uptake equivalent to 80% of the ventilatory threshold. Ventilation (VE) was measured breath by breath. Arterial oxyhemoglobin saturation (%SaO2) was determined by ear oximetry. After the switch into hyperoxia, VE remained unchanged from the steady-state exercise prehyperoxic value (60.6 +/- 6.5 l/min) during Acz. During control studies (Con), VE decreased from the prehyperoxic value (52.4 +/- 5.5 l/min) by approximately 20% (VE nadir = 42.4 +/- 6.3 l/min) within 20 s after the switch into hyperoxia. VE increased during Acz and Con after the switch into hypoxia; the hypoxic ventilatory response was significantly lower after Acz compared with Con [Acz, change (Delta) in VE/DeltaSaO2 = 1.54 +/- 0.10 l. min-1. SaO2-1; Con, DeltaVE/DeltaSaO2 = 2.22 +/- 0.28 l. min-1. SaO2-1]. The peripheral chemoreceptor contribution to the ventilatory drive after acute Acz-induced carbonic anhydrase inhibition is not apparent in the steady state of moderate-intensity exercise. However, Acz administration did not completely attenuate the peripheral chemoreceptor response to hypoxia.
B W Scheuermann; J M Kowalchuk; D H Paterson; D A Cunningham
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  86     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-28     Completed Date:  1999-06-28     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1544-51     Citation Subset:  IM; S    
Centre for Activity and Ageing, School of Kinesiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7.
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MeSH Terms
Acetazolamide / pharmacology
Anoxia / physiopathology
Bicycling / physiology
Blood Gas Analysis
Carbon Dioxide / blood
Carbonic Anhydrase Inhibitors / pharmacology*
Chemoreceptor Cells / drug effects*
Exercise / physiology*
Hyperoxia / physiopathology
Oxygen Consumption / drug effects,  physiology
Pulmonary Gas Exchange / drug effects
Respiratory Mechanics / drug effects,  physiology
Reg. No./Substance:
0/Carbonic Anhydrase Inhibitors; 124-38-9/Carbon Dioxide; 59-66-5/Acetazolamide

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