Document Detail


Peripheral chemoreceptor control of exercise hyperpnea in humans.
MedLine Citation:
PMID:  8183098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Estimates of the proportional contribution of the peripheral chemoreceptors (i.e., the carotid bodies) to human ventilatory control during moderate exercise (i.e., below the lactate threshold, theta L) suggest that they: (a) exert no discernible influence on the initial (usually rapid) phase I component; (b) provide significant modulation of the slower, exponential phase II dynamics, therefore contributing to the tightness of arterial PCO2 regulation and the magnitude of the transient hypoxemia in this phase; and (c) account for approximately 20% of the steady-state phase III drive, which can rise to over 50% in hypoxia (PaO2 approximately 50 mm Hg). Above theta L, the carotid bodies constrain the transient fall in arterial pH by mediating much (but not all) of the compensatory hyperventilation for the metabolic acidemia. The carotid body contribution above theta L, estimated by Dejours O2 testing, is not appreciably different from subthreshold estimates, suggesting that: (a) the respiratory alkalosis in blood and cerebrospinal fluid resulting from the hyperventilation may suppress carotid chemosensitivity; (b) an artifact resulting from secondary hyperoxia-induced stimulation of central chemoreceptors may lead to underestimation of the carotid body contribution; or (c) the carotid bodies may not be entirely "silenced" by hyperoxia during a metabolic acidemia.
Authors:
B J Whipp
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  26     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-06-15     Completed Date:  1994-06-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  337-47     Citation Subset:  IM; S    
Affiliation:
Department of Physiology, St. George's Hospital Medical School, London, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Carotid Body / physiology*
Chemoreceptor Cells / physiology*
Exercise / physiology*
Humans
Respiration / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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